| Alcohol embryo- and fetopathy. Neuropathology of 3 children and 3 fetuses. | |
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MedLine Citation:
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PMID: 438847 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Maternal chronic ethanol abuse during pregnancy causes malformations of the offspring. Three children (aged 6 months, 9 months, 4 1/2 years) and 3 fetuses (17th, 18th, and 20th gestational week) showed a wide spectrum of disorders ranging from severe dysraphic state, arhinencephaly, porencephaly, agenesis of corpus callosum, a range from hydranencephaly to microdysplasias (p.e. reduced gyration of dentate nucleus and inferior olives), and a range from gastrochisis or congenital heart defects to craniofacial dysmorphogenesis and palmar crease anomalies. The patterns of the cerebral malformations were not as uniform as the clinical phenotype of the alcohol embryopathy. The observations did not support the assumption that there exists a specific period for alcohol teratogenicity. |
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Authors:
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J Peiffer; F Majewski; H Fischbach; J R Bierich; B Volk |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the neurological sciences Volume: 41 ISSN: 0022-510X ISO Abbreviation: J. Neurol. Sci. Publication Date: 1979 Apr |
Date Detail:
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Created Date: 1979-07-25 Completed Date: 1979-07-25 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0375403 Medline TA: J Neurol Sci Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 125-37 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Drug-Induced* Alcoholism / complications* Brain / abnormalities Central Nervous System / abnormalities* Child, Preschool Female Humans Hydrocephalus / chemically induced Infant Male Maternal-Fetal Exchange* Meningocele / chemically induced Pregnancy Pregnancy Complications* Spinal Cord / abnormalities Thalamic Nuclei / abnormalities |
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