Document Detail

Alcohol embryo- and fetopathy. Neuropathology of 3 children and 3 fetuses.
MedLine Citation:
PMID:  438847     Owner:  NLM     Status:  MEDLINE    
Maternal chronic ethanol abuse during pregnancy causes malformations of the offspring. Three children (aged 6 months, 9 months, 4 1/2 years) and 3 fetuses (17th, 18th, and 20th gestational week) showed a wide spectrum of disorders ranging from severe dysraphic state, arhinencephaly, porencephaly, agenesis of corpus callosum, a range from hydranencephaly to microdysplasias (p.e. reduced gyration of dentate nucleus and inferior olives), and a range from gastrochisis or congenital heart defects to craniofacial dysmorphogenesis and palmar crease anomalies. The patterns of the cerebral malformations were not as uniform as the clinical phenotype of the alcohol embryopathy. The observations did not support the assumption that there exists a specific period for alcohol teratogenicity.
J Peiffer; F Majewski; H Fischbach; J R Bierich; B Volk
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  41     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  1979 Apr 
Date Detail:
Created Date:  1979-07-25     Completed Date:  1979-07-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  125-37     Citation Subset:  IM    
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MeSH Terms
Abnormalities, Drug-Induced*
Alcoholism / complications*
Brain / abnormalities
Central Nervous System / abnormalities*
Child, Preschool
Hydrocephalus / chemically induced
Maternal-Fetal Exchange*
Meningocele / chemically induced
Pregnancy Complications*
Spinal Cord / abnormalities
Thalamic Nuclei / abnormalities

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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