| Alcohol and race/ethnicity elicit different changes in lipid profiles in HIV-infected individuals receiving highly active antiretroviral therapy. | |
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MedLine Citation:
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PMID: 19427595 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This longitudinal study examined the impact of alcohol consumption (88 hazardous and 76 nonhazardous drinkers) and race/ethnicity on lipid profiles in individuals starting highly active antiretroviral therapy (HAART). At baseline, Whites and Hispanics had the most adverse lipid profiles, whereas Blacks had the least atherogenic. Whites and Hispanics showed higher increases in cholesterol (W = 11%; H = 6%), triglycerides (W = 40%; H = 24%), and low-density lipoprotein (10%) than Blacks (cholesterol = 4%; triglycerides = 9%; low-density lipoprotein = 4%). Hazardous alcohol consumption was correlated with increased lipids in each group. Hispanics had a clear trait risk for hypertriglyceridemia with HAART (1.9-fold) and with hazardous drinking (3.2-fold; p = .04). The highest risk for hypertriglyceridemia was found in heavy drinkers (3.75-fold; p = .05). Results underscore the importance of an alcohol/race interactive effect on HAART-associated dyslipidemia and the need for assessment and treatment of alcohol disorders. |
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Authors:
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Maria J Míguez-Burbano; John E Lewis; Robert Malow |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: The Journal of the Association of Nurses in AIDS Care : JANAC Volume: 20 ISSN: 1552-6917 ISO Abbreviation: J Assoc Nurses AIDS Care Publication Date: 2009 May-Jun |
Date Detail:
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Created Date: 2009-05-11 Completed Date: 2009-07-14 Revised Date: 2012-04-06 |
Medline Journal Info:
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Nlm Unique ID: 9111870 Medline TA: J Assoc Nurses AIDS Care Country: United States |
Other Details:
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Languages: eng Pagination: 176-83 Citation Subset: IM; N; X |
Affiliation:
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Department of Public Health, Florida International University, Miami, FL, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alcohol Drinking* Antiretroviral Therapy, Highly Active* Continental Population Groups* Ethnic Groups* Female HIV Infections / blood, drug therapy* Humans Lipids / blood* Longitudinal Studies Male Middle Aged |
| Grant Support | |
ID/Acronym/Agency:
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3R01 AA 017405-02S1/AA/NIAAA NIH HHS; 5R21 AA 13783-3/AA/NIAAA NIH HHS; R01 AA 639S1/AA/NIAAA NIH HHS; R01 AA018095-01A1/AA/NIAAA NIH HHS; R01 AA018095-02/AA/NIAAA NIH HHS; R01 AA018095-03/AA/NIAAA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Lipids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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