Document Detail


Alcohol during pregnancy and atopic dermatitis in the offspring.
MedLine Citation:
PMID:  15544590     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: There is evidence that antenatal factors play a role in the development of atopic dermatitis (AD). However, little is known about the effects of maternal lifestyle factors during pregnancy on the risk of AD in the offspring. OBJECTIVE: To investigate the effect of alcohol consumption during pregnancy on the incidence of AD in the offspring. METHODS: A total of 24 341 mother-child pairs enrolled in the Danish National Birth Cohort were followed prospectively. Information about alcohol consumption was obtained by interview at 12 and 30 weeks of gestation. Information about symptoms, time of onset, and doctor's diagnosis of AD in the offspring was obtained by interview at 18 months of age. The effect of alcohol consumption during pregnancy on the incidence of AD was analysed by Cox regression allowing for different effects of alcohol before (early infancy) and after 2 months (60 days) of age. RESULTS: Alcohol during pregnancy was associated with a significant and dose-dependent increased risk of AD in early infancy. This effect was mainly seen in high-risk infants (two parents with allergic disease). Thus, the highest risk of AD in early infancy was seen in high-risk infants of mothers who consumed four or more drinks per week at 30 weeks of gestation (adjusted relative risk 4.2, 95% confidence interval 1.7-10.1). There was no effect of alcohol during pregnancy beyond early infancy. CONCLUSIONS: The results suggest that alcohol during pregnancy increases the risk of early-onset AD in predisposed infants.
Authors:
A Linneberg; J Petersen; M Grønbaek; C S Benn
Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology     Volume:  34     ISSN:  0954-7894     ISO Abbreviation:  Clin. Exp. Allergy     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-11-16     Completed Date:  2005-04-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8906443     Medline TA:  Clin Exp Allergy     Country:  England    
Other Details:
Languages:  eng     Pagination:  1678-83     Citation Subset:  IM    
Affiliation:
Research Centre for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark. alli@glostruphosp.kbhamt.dk
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MeSH Terms
Descriptor/Qualifier:
Adult
Alcohol Drinking / epidemiology*
Denmark / epidemiology
Dermatitis, Atopic / chemically induced,  congenital*,  epidemiology
Epidemiologic Methods
Ethanol / administration & dosage,  toxicity
Female
Humans
Infant
Maternal-Fetal Exchange
Pregnancy / psychology*
Prenatal Exposure Delayed Effects*
Socioeconomic Factors
Chemical
Reg. No./Substance:
64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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