Document Detail

Alcohol drinking pattern during pregnancy and risk of infant mortality.
MedLine Citation:
PMID:  19797967     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The safety of small amounts of alcohol drinking and occasional binge-level drinking during pregnancy remains unsettled. We examined the association of maternal average alcohol intake and binge drinking (>or=5 drinks per sitting) with infant mortality, both in the neonatal and postneonatal period. METHODS: Participants were 79,216 mothers who were enrolled in the Danish National Birth Cohort in 1996-2002, gave birth to a live-born singleton, and provided information while they were pregnant on alcohol consumption during pregnancy. Information on infant mortality and causes of death was obtained from national registries and medical records. RESULTS: During the first year of life, 279 children (0.35%) died, 204 during the neonatal period. Infant mortality was not associated with alcohol drinking, even at a consumption level of either 4+ drinks per week or 3+ occasions of binge drinking. Postneonatal mortality was associated with an intake of 4+ drinks per week (hazard ratio = 3.56 [95% confidence interval = 1.15-8.43]) and with 3+ binge episodes (2.69 [1.27-5.69]). When restricting analyses to term births, both infant mortality and postneonatal mortality were associated with a weekly average intake of 4+ drinks or 3+ binge episodes. CONCLUSIONS: Among term infants, intake of at least 4 drinks of alcohol per week or binging on 3 or more occasions during pregnancy are associated with an increased risk of infant mortality, especially during the postneonatal period.
Katrine Strandberg-Larsen; Morten Gr??nboek; Anne-Marie Nybo Andersen; Per Kragh Andersen; J??rn Olsen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Epidemiology (Cambridge, Mass.)     Volume:  20     ISSN:  1531-5487     ISO Abbreviation:  Epidemiology     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-21     Completed Date:  2010-01-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9009644     Medline TA:  Epidemiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  884-91     Citation Subset:  IM    
Centre for Alcohol Research, National Institute of Public Health,University of Southern Denmark, Denmark.
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MeSH Terms
Alcohol Drinking / epidemiology*,  pathology
Denmark / epidemiology
Fetal Alcohol Syndrome / mortality*
Infant Mortality / trends*
Infant, Newborn
Proportional Hazards Models
Risk Assessment
Survival Analysis
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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