| Alcohol drinking determines the effect of the APOE locus on LDL-cholesterol concentrations in men: the Framingham Offspring Study. | |
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MedLine Citation:
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PMID: 11273848 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The effect of alcohol drinking on LDL-cholesterol concentrations is unclear. The reported variability may be due to interactions between genetic factors and alcohol intake. OBJECTIVE: The purpose of the study was to examine whether variation at the apolipoprotein E gene (APOE) locus modulates the association between alcohol drinking and LDL cholesterol. DESIGN: We used a cross-sectional design in a healthy population-based sample of 1014 men and 1133 women from the Framingham Offspring Study. RESULTS: In male nondrinkers (n = 197), LDL cholesterol was not significantly different across APOE allele groups [APOE*E2 (E2), APOE*E3 (E3), and APOE*E4 (E4)]. However, in male drinkers (n = 817), differences were observed (P: < 0.001); those with the E2 allele had the lowest concentrations. LDL cholesterol in men with the E2 allele was significantly lower in drinkers than in nondrinkers but was significantly higher in drinkers than in nondrinkers in men with the E4 allele. This APOE-alcohol interaction remained significant (P < 0.001) after age, body mass index, smoking status, and fat and energy intakes were controlled for. In women, the expected effect of APOE alleles on LDL cholesterol occurred in both drinkers (n = 791; P < 0.001) and nondrinkers (n = 342; P < 0.001). Multiple linear regression models showed a negative association (P < 0.05) between alcohol and LDL cholesterol in men with the E2 allele but a positive association in men with the E4 allele. No significant associations were observed in men or women with the E3 allele. CONCLUSION: In men, the effects of alcohol intake on LDL cholesterol are modulated in part by variability at the APOE locus. |
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Authors:
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D Corella; K Tucker; C Lahoz; O Coltell; L A Cupples; P W Wilson; E J Schaefer; J M Ordovas |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 73 ISSN: 0002-9165 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2001 Apr |
Date Detail:
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Created Date: 2001-03-29 Completed Date: 2001-04-19 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 736-45 Citation Subset: AIM; IM |
Affiliation:
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Lipid Metabolism Laboratory and the Epidemiology Program, Jean Mayer-US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Alcohol Drinking* / adverse effects, blood Alleles Apolipoproteins E / blood*, genetics* Cholesterol, LDL / blood*, genetics Cross-Sectional Studies Female Genotype Humans Lipids / blood* Male Middle Aged Polymorphism, Genetic Regression Analysis Sex Factors |
| Grant Support | |
ID/Acronym/Agency:
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HL54776/HL/NHLBI NIH HHS; N01-38038//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins E; 0/Cholesterol, LDL; 0/Lipids |
| Comments/Corrections | |
Comment In:
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Am J Clin Nutr. 2001 Apr;73(4):669-70
[PMID:
11273839
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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