Document Detail


Alcohol and the developing brain: neuroanatomical studies.
MedLine Citation:
PMID:  15303628     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
One of the distinguishing features of prenatal alcohol exposure is impaired cognitive and behavioral function resulting from damage to the central nervous system. Information available from the small number of autopsied cases in humans indicates that the offspring of mothers who abused alcohol during pregnancy have various neuroanatomical alterations ranging from gross reductions in brain size to cellular alterations. Recent neuroimaging technology provides the most powerful tool for assessing the neurotoxic effects of fetal alcohol exposure in living organisms and for exploring the relationship between behavioral dysfunction and brain damage at the regional level. Recently, animal research has suggested that the damaging effects of alcohol exposure during brain development could be prevented or attenuated by various pharmacological manipulations or by complex motor training. These promising findings provide directions for developing future prevention or intervention strategies.
Authors:
Wei-Jung A Chen; Susan E Maier; Scott E Parnell; James R West
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism     Volume:  27     ISSN:  1535-7414     ISO Abbreviation:  Alcohol Res Health     Publication Date:  2003  
Date Detail:
Created Date:  2004-08-11     Completed Date:  2004-08-26     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  100900708     Medline TA:  Alcohol Res Health     Country:  United States    
Other Details:
Languages:  eng     Pagination:  174-80     Citation Subset:  IM    
Affiliation:
Department of Human Anatomy and Medical Neurobiology, College of Medicine, Texas A&M University System Health Science Center, College Station, Texas, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / anatomy & histology*,  drug effects*,  growth & development
Diagnostic Imaging / methods
Ethanol / adverse effects*
Female
Humans
Pregnancy
Prenatal Exposure Delayed Effects*
Chemical
Reg. No./Substance:
64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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