Document Detail


Alcohol consumption and serum hormone levels during pregnancy.
MedLine Citation:
PMID:  16257353     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Factors that change sex hormone levels during pregnancy may have long-term health consequences for the offspring, including changes in breast cancer risk. A cross-sectional analysis of alcohol consumption and hormone levels in 339 pregnant women sampled from the Child Health and Development Study cohort was undertaken. Alcohol intake was queried from 1959 to 1966, long before any hazards of drinking during pregnancy were publicized. Third trimester serum hormone levels including estradiol and testosterone were analyzed. Among 339 pregnant women, 196 reported some alcohol consumption during pregnancy. The drinkers were divided into three groups with intake levels of 0.2-0.5, 0.6-2.0, and 2.1-12.5 ounces of ethanol per week. The second group corresponds to a median intake of approximately 2 drinks per week, and the last group corresponds to a median intake of approximately 1 drink per day, which is considered "light" to "moderate" drinking. Maternal estradiol levels were not associated with alcohol intake during pregnancy. However, serum testosterone was significantly lower, by 12.2%, in the latter two groups of drinking pregnant women, [confidence interval (CI)=-3.0 to 25.2] and 25.6% (CI=9.2-39.5), respectively. The alcohol intakes reported are far below those shown to cause fetal alcohol syndrome, or any of the fetal alcohol effects so far studied. Light alcohol intake during pregnancy is associated with lower maternal testosterone. The health implications are uncertain, but may include an increased breast density in the daughters of drinking mothers.
Authors:
Richard G Stevens; Richard D Cohen; Mary Beth Terry; Bill L Lasley; Pentti Siiteri; Barbara A Cohn
Related Documents :
18442893 - Respiratory effects of chronic in utero methadone or morphine exposure in the neonatal ...
19553703 - Ethylglucuronide and ethylsulfate in meconium to assess gestational ethanol exposure: p...
21232003 - Impact of common thrombophilias and jak2 v617f on pregnancy outcomes in unselected ital...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Alcohol (Fayetteville, N.Y.)     Volume:  36     ISSN:  0741-8329     ISO Abbreviation:  Alcohol     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-10-31     Completed Date:  2005-12-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8502311     Medline TA:  Alcohol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  47-53     Citation Subset:  IM    
Affiliation:
Department of Community Medicine, University of Connecticut Health Center, 263 Farmington Ave., Farmington, CT 06030, USA. bugs@neuron.uchc.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Alcohol Drinking / blood*
Estradiol / blood*
Female
Humans
Pregnancy / blood*
Testosterone / blood*
Grant Support
ID/Acronym/Agency:
N01 HD13334/HD/NICHD NIH HHS; N01 HD63258/HD/NICHD NIH HHS; R21 ES11659/ES/NIEHS NIH HHS; R21 ES11677/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
50-28-2/Estradiol; 58-22-0/Testosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Regulation of alcohol intake with advancing age.
Next Document:  Different stages in the temporal course of estrogen treatment produce opposite effects on voluntary ...