Document Detail

Alcohol consumption and outcome in stable outpatients with peripheral artery disease.
MedLine Citation:
PMID:  21684714     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The influence of alcohol consumption on outcome in patients with peripheral artery disease (PAD) has not been thoroughly studied.
METHODS: Factores de Riesgo y ENfermedad Arterial (FRENA) is an ongoing, multicenter, observational registry of consecutive stable outpatients with arterial disease. We compared the mortality rate and the incidence of subsequent ischemic events in patients with PAD, according to their alcohol habits.
RESULTS: As of August 2010, 1073 patients with PAD were recruited, of whom 863 (80%) had intermittent claudication (Fontaine stage II), 102 (9.5%) had rest pain (Fontaine stage III), and 108 (10%) had ischemic skin lesions (Fontaine stage IV). In all, 422 patients (39%) consumed alcohol during the study period. Over a mean follow-up of 13 months, 150 patients (14%) developed subsequent ischemic events (myocardial infarction 28, stroke 30, disabling claudication/critical limb ischemia 100), and 70 patients (6.5%) died. The incidence of subsequent events was the same in both subgroups: 11.8 events per 100 patient-years (rate ratio: 1.00; 95% confidence interval [CI], 0.72-1.41), but the mortality rate was significantly lower in alcohol consumers than in non-consumers: 2.78 vs 6.58 deaths per 100 patient-years (rate ratio: 0.42; 95% CI, 0.23-0.74; P = .002). This better outcome was consistently found in patients with Fontaine stages II and III or IV, and persisted after multivariate adjustment (relative risk: 0.49; 95% CI, 0.28-0.88).
CONCLUSIONS: In patients with PAD, moderate alcohol consumption was associated with lower cardiovascular mortality and overall mortality than abstention. These patients should be informed that low to moderate alcohol consumption may not be harmful to their health.
Ana Maria Garcia-Diaz; Pablo Javier Marchena; Jesús Toril; Gemma Arnedo; Juan Francisco Sanchez Muñoz-Torrero; Montserrat Yeste; Eduardo Aguilar; Manuel Monreal;
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Publication Detail:
Type:  Journal Article; Multicenter Study    
Journal Detail:
Title:  Journal of vascular surgery     Volume:  54     ISSN:  1097-6809     ISO Abbreviation:  J. Vasc. Surg.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-05     Completed Date:  2011-11-18     Revised Date:  2012-10-03    
Medline Journal Info:
Nlm Unique ID:  8407742     Medline TA:  J Vasc Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1081-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Society for Vascular Surgery. Published by Mosby, Inc. All rights reserved.
Primary Healthcare, ABS Gaudi, Barcelona, Spain.
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MeSH Terms
Alcohol Drinking / epidemiology*,  mortality
Brain Ischemia / etiology
Chi-Square Distribution
Disability Evaluation
Intermittent Claudication / diagnosis,  epidemiology*,  mortality
Ischemia / diagnosis,  epidemiology*,  mortality
Logistic Models
Middle Aged
Myocardial Infarction / epidemiology
Odds Ratio
Outpatients / statistics & numerical data*
Peripheral Arterial Disease / diagnosis,  epidemiology*,  mortality
Proportional Hazards Models
Prospective Studies
Risk Assessment
Risk Factors
Severity of Illness Index
Spain / epidemiology
Stroke / etiology
Temperance / statistics & numerical data
Time Factors
E Aguilar / ; J N Alcalá-Pedrajas / ; L R Alvarez / ; G Arnedo / ; R Coll / ; A García-Díaz / ; L López-Jiménez / ; M Monreal / ; M T Pascual / ; J C Sahuquillo / ; J F Sánchez Muñoz-Torrero / ; C Sanclemente / ; J M Suriñach / ; J Toril / ; M Yeste /

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