Document Detail

Alcohol consumption in the absence of adequate nutrition may lead to activation of the glyoxylate cycle in man.
MedLine Citation:
PMID:  12056879     Owner:  NLM     Status:  MEDLINE    
The consumption of alcohol prior to food intake results in alcohol metabolism occurring in the liver, and the liver is often damaged in chronic alcoholics. This paper highlights the possibility that alcohol consumption in the absence of adequate nutrition after an extended period of time may lead to activation of the glyoxylate cycle, an energy pathway associated with the conversion of fat into carbohydrate which until recently was thought to only exist in plants and bacteria.
A Kokavec; S F Crowe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical hypotheses     Volume:  58     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-06-11     Completed Date:  2003-02-06     Revised Date:  2008-08-15    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  411-5     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Published by Elsevier Science Ltd.
School of Psychological Science, La Trobe University, Bundoora, Australia.
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MeSH Terms
Alcohol Drinking / adverse effects*,  metabolism*
Carbohydrate Metabolism
Energy Metabolism / drug effects
Ethanol / metabolism,  toxicity
Glyoxylates / metabolism*
Lipid Metabolism
Liver / drug effects,  metabolism
Models, Biological
Reg. No./Substance:
0/Glyoxylates; 298-12-4/glyoxylic acid; 64-17-5/Ethanol

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