Document Detail


Alcohol consumption by young actively growing rats: a histomorphometric study of cancellous bone.
MedLine Citation:
PMID:  9113275     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Alcohol consumption by young actively growing rats has been previously demonstrated to decrease bone density. This study addresses the mechanism of alcohol action on the early phases of bone growth and development using histomorphometric techniques. Four-week-old, female Sprague-Dawley rats were divided into three groups. Alcohol-treated animals were fed a modified Lieber-DeCarli diet ad libitum containing 35% ethanol-derived calories, whereas the pair-fed animals (weight-matched to ethanol rats) received an isocaloric liquid diet in which maltose-dextrin-substituted calories were supplied by ethanol. Chow animals were fed a standard rat chow ad libitum. Proximal tibiae, including epiphyseal growth plate, were removed for analysis after 2, 4, 6, or 8 weeks on the diets. Trabecular volume and number were greatly reduced in the alcohol-fed animals; however, bone formation rates and mineralization rates were normal. Epiphyseal growth rate and proliferation rate were essentially stopped in the alcohol-fed animals.
Authors:
H W Sampson; C Chaffin; J Lange; B DeFee
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Alcoholism, clinical and experimental research     Volume:  21     ISSN:  0145-6008     ISO Abbreviation:  Alcohol. Clin. Exp. Res.     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-07-22     Completed Date:  1997-07-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7707242     Medline TA:  Alcohol Clin Exp Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  352-9     Citation Subset:  IM    
Affiliation:
Department of Human Anatomy and Neurobiology, College of Medicine, Texas A&M University Health Science Center, College Station 77843-1114, USA.
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MeSH Terms
Descriptor/Qualifier:
Alcoholism / pathology*
Animals
Bone Density / drug effects*
Bone Development / drug effects*
Bone and Bones / drug effects,  pathology
Ethanol / toxicity*
Female
Growth Plate / drug effects,  pathology
Rats
Rats, Sprague-Dawley
Grant Support
ID/Acronym/Agency:
AA10234/AA/NIAAA NIH HHS
Chemical
Reg. No./Substance:
64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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