| Alcohol consumption and breast cancer oestrogen and progesterone receptor status. | |
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MedLine Citation:
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PMID: 10098777 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We examined the role of alcohol on the risk of breast cancer by the joint oestrogen receptor (ER) and progesterone receptor (PR) status of the tumour using data from two case-control studies conducted in Los Angeles County, USA. Eligible premenopausal patients were 733 women aged < or =40 years and first diagnosed from 1 July 1983 to 1 January 1989. Eligible postmenopausal patients were 1169 women aged 55-64 years and first diagnosed from 1 March 1987 to 31 December 89. Patients were identified by the University of Southern California Cancer Surveillance Program. Neighbourhood controls were individually matched to patients by parity (premenopausal patients) and birth date (+/-3 years). ER and PR status were obtained from medical records for 424 premenopausal and 760 postmenopausal patients. The analyses included 714 premenopausal and 1091 postmenopausal control subjects. Alcohol use was generally not associated with premenopausal risk of breast cancer, regardless of hormone-receptor status. Among the postmenopausal women, those who consumed, on average, > or =27 g of alcohol/d experienced an odds ratio (OR) of 1.76 [95% confidence interval (CI) 1.14-2.71] for ER-positive/PR-positive breast cancer relative to women who reported no alcohol consumption. Alcohol use was less clearly associated with risk of other receptor types among postmenopausal women. These data suggest that alcohol may preferentially increase risk of ER-positive/PR-positive breast cancer in postmenopausal women. |
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Authors:
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S M Enger; R K Ross; A Paganini-Hill; M P Longnecker; L Bernstein |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: British journal of cancer Volume: 79 ISSN: 0007-0920 ISO Abbreviation: Br. J. Cancer Publication Date: 1999 Mar |
Date Detail:
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Created Date: 1999-04-13 Completed Date: 1999-04-13 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0370635 Medline TA: Br J Cancer Country: SCOTLAND |
Other Details:
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Languages: eng Pagination: 1308-14 Citation Subset: IM |
Affiliation:
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Research and Evaluation Department, Kaiser Permanente Medical Care Program, Southern California, Pasadena 91188, USA. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alcohol Drinking / adverse effects* Analysis of Variance Body Mass Index Breast Neoplasms / metabolism* Case-Control Studies Female Humans Middle Aged Postmenopause / metabolism* Premenopause / metabolism* Receptors, Estrogen / metabolism* Receptors, Progesterone / metabolism* Risk Assessment |
| Grant Support | |
ID/Acronym/Agency:
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CA17054/CA/NCI NIH HHS; CA44546/CA/NCI NIH HHS; N01-CN25404/CN/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Estrogen; 0/Receptors, Progesterone |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
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Journal Information Journal ID (nlm-ta): Br J Cancer ISSN: 0007-0920 ISSN: 1532-1827 Publisher: Nature Publishing Group |
Article Information Download PDF  Copyright 1999, Cancer Research Campaign Received Day: 05 Month: 08 Year: 1998 Revision Received Day: 06 Month: 10 Year: 1998 Accepted Day: 07 Month: 10 Year: 1998 Print publication date: Month: 03 Year: 1999 Volume: 79 Issue: 7/8 First Page: 1308 Last Page: 1314 ID: 2362214 Publisher Item Identifier: 6690210 DOI: 10.1038/sj.bjc.6690210 PubMed Id: 10098777 |
| Alcohol consumption and breast cancer oestrogen and progesterone receptor status | |
| S M Enger12 | |
| R K Ross2 | |
| A Paganini-Hill2 | |
| M P Longnecker3 | |
| L Bernstein2 | |
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1Research and Evaluation Department, Kaiser Permanente Medical Care Program, Pasadena, Southern California, CA 91188, USA |
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2Department of Preventive Medicine, University of Southern California and Norris Comprehensive Cancer Center, Los Angeles, CA 90033, USA |
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3Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA |
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| *Author for correspondence: |
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Article Categories:
Keywords: alcohol, oestrogen receptors, progesterone receptors, breast neoplasms, epidemiology. |
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