|Alcohol and cause-specific mortality in Russia: a retrospective case-control study of 48,557 adult deaths.|
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|PMID: 19560602 Owner: NLM Status: MEDLINE|
|BACKGROUND: Alcohol is an important determinant of the high and fluctuating adult mortality rates in Russia, but cause-specific detail is lacking. Our case-control study investigated the effects of alcohol consumption on male and female cause-specific mortality.
METHODS: In three Russian industrial cities with typical 1990s mortality patterns (Tomsk, Barnaul, Biysk), the addresses of 60,416 residents who had died at ages 15-74 years in 1990-2001 were visited in 2001-05. Family members were present for 50,066 decedents; for 48,557 (97%), the family gave proxy information on the decedents' past alcohol use and on potentially confounding factors. Cases (n=43,082) were those certified as dying from causes we judged beforehand might be substantially affected by alcohol or tobacco; controls were the other 5475 decedents. Case versus control relative risks (RRs; calculated as odds ratios by confounder-adjusted logistic regression) were calculated in ever-drinkers, defining the reference category by two criteria: usual weekly consumption always less than 0.5 half-litre bottles of vodka (or equivalent in total alcohol content) and maximum consumption of spirits in 1 day always less than 0.5 half-litre bottles. Other ever-drinkers were classified by usual weekly consumption into three categories: less than one, one to less than three, and three or more (mean 5.4 [SD 1.4]) bottles of vodka or equivalent.
FINDINGS: In men, the three causes accounting for the most alcohol-associated deaths were accidents and violence (RR 5.94, 95% CI 5.35-6.59, in the highest consumption category), alcohol poisoning (21.68, 17.94-26.20), and acute ischaemic heart disease other than myocardial infarction (3.04, 2.73-3.39), which includes some misclassified alcohol poisoning. There were significant excesses of upper aerodigestive tract cancer (3.48, 2.84-4.27) and liver cancer (2.11, 1.64-2.70). Another five disease groups had RRs of more than 3.00 in the highest alcohol category: tuberculosis (4.14, 3.44-4.98), pneumonia (3.29, 2.83-3.83), liver disease (6.21, 5.16-7.47), pancreatic disease (6.69, 4.98-9.00), and ill-specified conditions (7.74, 6.48-9.25). Although drinking was less common in women, the RRs associated with it were generally more extreme. After correction for reporting errors, alcohol-associated excesses accounted for 52% of all study deaths at ages 15-54 years (men 8182 [59%] of 13968, women 1565 [33%] of 4751) and 18% of those at 55-74 years (men 3944 [22%] of 17,536, women 1493 [12%] of 12 302). Allowance for under-representation of extreme drinkers would further increase alcohol-associated proportions. Large fluctuations in mortality from these ten strongly alcohol-associated causes were the main determinants of recent fluctuations in overall mortality in the study region and in Russia as a whole.
INTERPRETATION: Alcohol-attributable mortality varies by year; in several recent years, alcohol was a cause of more than half of all Russian deaths at ages 15-54 years. Alcohol accounts for most of the large fluctuations in Russian mortality, and alcohol and tobacco account for the large difference in adult mortality between Russia and western Europe.
FUNDING: UK Medical Research Council, Cancer Research UK, British Heart Foundation, International Agency for Research on Cancer, and European Commission Directorate-General for Research.
|David Zaridze; Paul Brennan; Jillian Boreham; Alex Boroda; Rostislav Karpov; Alexander Lazarev; Irina Konobeevskaya; Vladimir Igitov; Tatiana Terechova; Paolo Boffetta; Richard Peto|
|Type: Journal Article; Research Support, Non-U.S. Gov't|
|Title: Lancet Volume: 373 ISSN: 1474-547X ISO Abbreviation: Lancet Publication Date: 2009 Jun|
|Created Date: 2009-06-29 Completed Date: 2009-07-17 Revised Date: 2014-02-19|
Medline Journal Info:
|Nlm Unique ID: 2985213R Medline TA: Lancet Country: England|
|Languages: eng Pagination: 2201-14 Citation Subset: AIM; IM|
|APA/MLA Format Download EndNote Download BibTex|
Alcoholism / mortality*
Cause of Death / trends*
Confounding Factors (Epidemiology)
Cost of Illness
Mortality / trends
Sensitivity and Specificity
Siberia / epidemiology
Urban Health / statistics & numerical data
|MC_U137686857//Medical Research Council; //British Heart Foundation; //Cancer Research UK; //Medical Research Council|
Lancet. 2009 Jun 27;373(9682):2176-7
Lancet. 2009 Sep 19;374(9694):975; author reply 975-6 [PMID: 19766875 ]
Journal ID (nlm-ta): Lancet
Publisher: Lancet Publishing Group
© 2009 Elsevier Ltd. All rights reserved..
License:This document may be redistributed and reused, subject to certain conditions.
Print publication date: Day: 27 Month: 6 Year: 2009
Volume: 373 Issue: 9682
First Page: 2201 Last Page: 2214
PubMed Id: 19560602
Publisher Id: LANCET61034
|Alcohol and cause-specific mortality in Russia: a retrospective case–control study of 48 557 adult deaths|
|David Zaridzea*||Email: email@example.com|
|Richard Petoc**||Email: firstname.lastname@example.org|
aRussian Cancer Research Centre, Moscow, Russia
bInternational Agency for Research on Cancer, Lyon, France
cClinical Trial Service Unit and Epidemiological Studies Unit (CTSU), University of Oxford, Oxford, UK
dInstitute of Cardiology, Tomsk Research Centre, Tomsk, Russia
eAltai Branch of Russian Cancer Research Centre, Barnaul, Russia
|*Correspondence to: Prof David Zaridze, Department of Epidemiology and Prevention, N N Blokhin Russian Cancer Research Centre, Kashirskoye Shosse 24, 115478 Moscow, Russia email@example.com
**Correspondence to: Prof Sir Richard Peto, CTSU, Richard Doll Building, Old Road Campus, Oxford OX3 7LF, UK firstname.lastname@example.org
The sharp fluctuations in Russian adult mortality rates since 1984 (figure 1 and panel 1) are unprecedented in a modern industrialised country. Although the largest relative changes were in the mortality attributed directly to alcohol poisoning, the largest absolute changes were in the mortality attributed to other external causes and to vascular disease.4,5 Within vascular disease mortality, that from acute myocardial infarction was relatively low and stable; the greatest absolute fluctuations were in the mortality attributed on the death certificate to other forms of acute ischaemic heart disease, some of which represented misclassified alcohol poisoning.6 The lowest overall mortality rates were in 1986–87, following the 1985 Soviet restrictions on alcohol production; previously, alcohol consumption had been increasing slowly for many years, but it decreased suddenly within a few months during 1985, was at a minimum during 1986–87 at about three-quarters of pre-1985 levels, increased (slowly then steeply) after 1987, and was at a maximum in 1994. The highest overall mortality rates also occurred in 1994, following the Soviet collapse in late 1991.7,8 The relative changes in mortality were particularly extreme at ages 15–54 years. At these ages, both male and female Russian death rates approximately doubled between 1987 and 1994, then fluctuated but remained high (figure 1). At the death rates of the year 2000,7 the probability that a 15-year-old man would die before age 35 years was almost 10%, and the probability that a 35-year-old man would die before age 55 years was 27%; in western Europe these probabilities were only 2% and 6%, respectively.1–3
Evidence of a major effect of alcohol consumption on recent Russian mortality patterns comes from both cause-specific analyses of national mortality trends4–10 and analytical studies of individuals.11–14 These effects need to be measured reliably not only to assess the importance of alcohol, but also to help determine whether the main societal factors that underlie the Russian mortality fluctuations (eg, general economic uncertainty15,16 or destabilising effects of rapid mass privatisation17) had any major effects on mortality other than through their effects on drinking patterns. A case–control study in Izhevsk based on proxy information from families of 1750 men who died in 2003–05 reported that 43% of male deaths at ages 25–54 years were caused by ethanol (either in vodka and other beverages intended for human consumption or in other products [non-beverage alcohol]).14 To assess the effects of alcohol consumption on male and female mortality in a wider range of ages (15–74 years) and over a longer period (1990–2001) than in previous analytical studies, and to assess more reliably its role in specific causes of death, between 2001 and 2005 we obtained proxy information on alcohol consumption and other lifestyle factors from families of 48 557 Russian adults who had died in 1990–2001, and related this information to the certified cause of death.
This case–control study took place in three industrial cities of western Siberia with predominantly European Russian populations: Tomsk (2002 census population 0·5 million), Barnaul (0·7 million) and Biysk (0·2 million). Overall mortality rates (and the distribution of the main certified causes of death) were similar to those in the whole of Russia, and fluctuated in a similar way during the 1990s, with a sudden large increase in mortality during 1992–94.5 Details, including name, address, age, and sex, of the 0·2 million registered residents who died at ages 15–74 years during 1990–2001 in these three cities were taken from local death registration records. Such records include virtually all urban deaths (but, until 2002, excluded deaths of migrants to the three cities). For each death record we ignored the local death coding,5 and used the International Classification of Diseases and Related Health Problems 10th revision (ICD-10) to assign the underlying cause from the written death certificate.18
During 2001–05, teams of local physicians were trained in objective interview methods and worked (under supervision) mainly in those areas of town in which at least one had practised (although most were currently not doing so; this study was not identified with local health-care services). Working from lists that did not record causes of death, they visited, usually after 1800 h, 60 416 addresses of decedents; the adult family members found at these addresses were asked to participate in an interview, mainly about their own habits. Questions about decedents did not dominate the interview, since interviewers first completed standard questionnaires about smoking, drinking, and other factors for all adults present (for future prospective study). A fixed sequence was used to select a competent adult informant for the deceased individual; spouses were the first choice, then siblings, then parents, then adult children, then any other adult family member. Informants could be blood or in-law relatives living at the address. One in ten interviews about decedents was randomly chosen for repetition to monitor performance. Alcohol questions did not obtrude, because much other information was obtained, including ethnicity, marital status, education level, jobs held, job loss, income, recent changes in income, and smoking (usual daily amount, age started, age stopped). Smokers were defined as those who had smoked within 5 years of death or after age 55 years.
The questionnaire used in the interview asked about usual alcohol consumption patterns before the final year of life (usual weekly frequency of drinking spirits, beer, and wine, usual amounts of each per session, and maximum amount [just of spirits] per session). The main spirit used was vodka; other spirits are taken as equivalent in strength (ie, 40% alcohol). Beer was taken as 0·125 and wine as 0·25 times vodka in strength. Total weekly alcohol consumption (frequencies multiplied by usual amounts) was expressed in 500 mL bottles of vodka (or alcoholic equivalent). The same questions were asked about the final year of life, but the usual amounts reported for the two periods were similar, and only the greater of the two was used.
In ever-drinkers, the reference category was defined by two upper limits: usual weekly alcohol consumption always less than 0·5 bottles of vodka (or equivalent), and, to exclude binge drinkers, maximum consumption of spirits per session always less than 0·5 bottles. Other ever-drinkers were categorised only by weekly consumption (<one, one to <three, or ≥three bottles of vodka or equivalent), and relative risks and trend tests compare these three categories with the reference category. For decedents aged 15–39 years, interviewers also recorded regular drinking (yes/no) of non-beverage alcohol, but this information was not used in defining the alcohol categories.
Alcohol intake is difficult to assess reliably in proxy interviews several years after death. Moreover, if death was from a disease (or external cause) substantially affected by alcohol, families might tend to misreport amounts or even report no alcohol use, leading some drinkers to be misclassified as never-drinkers. Since real never-drinking is rare in Russia, at least in men, this could make the ratio of proxy-reported never-drinkers to ever-drinkers differ substantially between those who died from alcohol-affected diseases (or external causes) and other diseases. The main case–control analyses therefore ignore the small numbers reported as never-drinkers, compare the four categories of ever-drinkers, and make approximate correction for the effects of uncertainty in alcohol use. Sensitivity analyses include the never-drinkers.
The case–control comparisons relate alcohol consumption category (reference or other) among ever-drinkers to underlying cause of death (case or control). Cases were those who had died from the causes that, in our prior judgment, could be substantially affected by alcohol or tobacco: alcohol poisoning (redefined to include the few deaths from alcoholic psychosis), other external causes, ill-defined causes, tuberculosis, respiratory disease, vascular disease, oesophagus, stomach, liver, or pancreas disease (apart from diabetes mellitus) and lung, upper aerodigestive tract, stomach, liver, pancreas, bladder, or breast cancer. Controls were those adults who had died from other diseases, including some malignant neoplasms, all benign neoplasms, diabetes, diseases of the nervous system, non-alcoholic mental disorders, renal disease, and all infectious or parasitic diseases other than tuberculosis, pneumonia, or hepatitis.
The main analyses are of ever-drinkers, and compare four alcohol categories. Case versus control odds ratios for the three higher alcohol categories (versus reference drinkers) were calculated simultaneously by logistic regression, stratified for age (in 5-year age-groups), city (three cities) and smoking (yes/no), and are described as relative risks (RRs, calculated as odds ratios by SAS version 9.1). For deaths in one alcohol category, the RR implies that the dose-related excess proportion is 1–1/RR. Sensitivity analyses involved cruder alcohol categories but more stratification. 95% CIs, trend tests, and two-sided p values are cited, making no allowance for multiple hypothesis testing.
The sponsors of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report. The corresponding authors had full access to all the data in the study and had final responsibility for the decision to submit for publication.
Family members were found at 50 066 (83%) of the 60 416 addresses visited. 97% of interviews were completed, yielding information on 48 557 decedents (31 504 men, 17 053 women), of whom 43 082 were cases and 5475 were controls. Table 1 shows year of death, relationship of interviewee to deceased individual, certified causes of death, and, for controls (97% [5309/5475] of whom were ethnic Russian), their reported habits. Of 2514 male controls, 212 (8%) never drank alcohol, 363 (14%) were in the reference category, and 1939 (77%) were in the higher alcohol consumption categories. Of 2961 female controls, 903 (30%) never drank, 1479 (50%) were in the reference category, and only 579 (20%) were in the higher alcohol consumption categories. Within each category, however, male and female controls had similar consumption patterns. On average, those in the top category drank on 4·8 (SD 1·6) days a week, consuming 5·4 (1·4) half-litre bottles of vodka (or equivalent) a week, with maximum consumption of spirits in 1 day mostly reported as one bottle or two bottles (mean 1·4 [0·6] bottles). On average, those in the other three categories of ever-drinkers (ie, reference, <one bottle, or one to <three bottles) drank on 0·4 (0·6), 0·8 (0·8), or 2·2 (1·2) days a week, consuming 0·1 (0·1), 0·3 (0·3), or 1·5 (0·5) bottles of vodka (or equivalent) a week, with maximum spirits in 1 day 0·2 (0·1), 0·7 (0·3), or 1·0 (0·4) bottles.
Table 2 gives the main results for male mortality at ages 15–74 years in ever-drinkers, subdivided by cause and amount drunk. For neoplastic disease, the trend in risk across categories of ever-drinkers was significant only for upper aerodigestive tract cancer (RR 3·48, 95% CI 2·84–4·27, in the highest alcohol consumption category; trend p<0·0001) and liver cancer (2·11, 1·64–2·70; trend p<0·0001). The trends were not significant for lung cancer (p=0·18) or stomach cancer (p=0·46).
Six non-neoplastic disease groups were also strongly associated with alcohol in men, with RRs greater than 3·00 in the highest consumption category (all p<0·0001 for the trend in risk). These disease groups were tuberculosis (4·14, 3·44–4·98), pneumonia (3·29, 2·83–3·83), liver disease (6·21, 5·16–7·47), pancreatic disease (6·69, 4·98–9·00), acute ischaemic heart disease (IHD) other than myocardial infarction (3·04, 2·73–3·39), and death from an ill-specified disease (7·74, 6·48–9·25). The latter two groups include some misclassified deaths that were actually from alcohol poisoning.6 Some other causes of death were significantly associated with alcohol, but the RRs were less extreme (eg, stroke [1·28, 1·15–1·43]). There was, however, no significant trend in mortality from acute myocardial infarction (p=0·62); in the heaviest drinkers (three or more bottles per week), acute myocardial infarction accounted for only 178 deaths, whereas acute IHD other than myocardial infarction accounted for 1044 deaths.
In the combined results for all causes of death strongly associated with alcohol in men (ie, liver cancer and anything with RR more than 3·00 in table 2) there was, of course, a definite and progressive dose-response relation (with RR 3·77, 3·44–4·12, for men in the highest alcohol category), whereas in the combined results for all other diseases the progressive association, although significant, was less strong (1·40, 1·29–1·52).
As expected, reported alcohol consumption was strongly associated with the mortality that was certified as caused by alcohol poisoning, but 41 (3%) of 1610 ever-drinkers who died from alcohol poisoning were in the lowest alcohol category (reference category), and a further 11 were reported as never-drinkers, indicating that proxy information sometimes missed life-threatening alcohol use. Moreover, another 188 (12%) deaths from alcohol poisoning were in men whose usual consumption was, perhaps inaccurately, reported to be less than one bottle per week. Reported alcohol consumption was also strongly associated with the other major groups of external causes of death, including transport accidents (4·20, 3·31–5·34), other accidents (6·07, 5·27–6·98), suicide (8·62, 6·99–10·62), and assault (9·47, 7·96–11·25; all p<0·0001 for the trend in risk).
Table 3 gives the corresponding results for women. For neoplastic disease, the RR in the highest drinking category appeared to be increased only for liver cancer and upper aerodigestive tract cancer, although no trend in cancer mortality was significantly positive (perhaps because of small numbers). For breast cancer, the trend was significantly negative (p=0·0002), and the relative risks in the two highest alcohol consumption categories were both substantially lower than 1·00.
The non-neoplastic disease groups that were most strongly associated with alcohol in men were even more strongly associated with alcohol in women, each with an RR of more than 3·00 not only in the heaviest drinkers but also in women drinking one to three bottles of vodka (or equivalent) per week (and each with p<0·0001 for trend). The same findings were seen for each main group of external causes, including transport accidents, other accidents, suicide, and assault. As in men, reported alcohol consumption in women was strongly associated with mortality from alcohol poisoning, but in the 424 female ever-drinkers certified as dying from alcohol poisoning, 51 (12%) were in the lowest alcohol category (reference category), and another 41 (10%) were reported to have usually consumed less than one bottle of vodka (or equivalent) per week. Again, the RR was substantially less extreme for acute myocardial infarction than for other acute IHD, and in the top two alcohol consumption categories, only 64 women died from acute myocardial infarction compared with 463 from other acute IHD.
Table 4 subdivides the results for all men more narrowly by age (15–54 years and 55–74 years) and groups the causes as alcohol poisoning, accidents and violence, diseases strongly associated with alcohol in this study, other non-control diseases, and control diseases. (The strongly associated diseases were liver disease, liver cancer, upper aerodigestive cancer, and other disease groups with RR more than 3·00 for men with usual consumption three or more bottles of vodka per week [tuberculosis, pneumonia, acute IHD other than myocardial infarction, non-neoplastic pancreatic disease, and ill-specified disease].) The relative risks comparing never-drinkers with reference drinkers are consistent with families under-reporting moderate alcohol use more in men who had died from accidents, violence, and diseases strongly associated with alcohol than in men who had died from other diseases. This finding is particularly clear for men aged 55–74 years, in whom the ratio of reported never-drinkers to reference drinkers was 1·1 ([88+371]/[87+317]) for men who had died of accidents, violence, and diseases strongly associated with alcohol, compared with only 0·4 ([560+98]/[1266+223]) in men who had died of other diseases (p<0·0001 for difference in ratios).
Table 5 gives corresponding results for women. Discrepancies between never-drinkers and reference drinkers are less extreme than in men, but are still apparent, particularly at ages 55–74 years. The ratio of never-drinkers to reference drinkers at these ages was 0·9 (742/832) for female deaths from accidents, violence, and the diseases strongly associated with alcohol, and only 0·5 (2623/4868) for female deaths from other diseases, again consistent with variable under-reporting of moderate alcohol use.
The relative risks in ever-drinkers (which compare the three higher alcohol consumption categories with the reference category) might be more directly indicative of real associations. Even in ever-drinkers, however, substantial misclassification of real alcohol consumption patterns is inevitable. If some alcohol-associated deaths are included in the reference category, then uncorrected calculation of alcohol-dose-related excess mortality in the other three alcohol consumption categories will underestimate the real excess mortality. Exact correction for this is impossible, but approximate correction for it is made in tables 4 and 5 by multiplying the uncorrected excess mortality from each cause by a common factor, calculated within each age range to ensure that the corrected dose-related excess is 100% for the deaths from alcohol poisoning. At ages 15–54 years, the alcohol dose-related excess accounted for 6712 (48%) of 13 968 male deaths in the uncorrected calculations, and 8182 (59%) of 13 968 in the corrected calculations. Of the corrected excess, 90% ([1163+3756+2432]/8182 deaths) was from alcohol poisoning, accidents, violence, and the eight disease groups that are strongly related to alcohol; of the remaining 10% (831/8182 excess deaths in men at ages 15–54 years), much was from vascular disease. The corrected alcohol dose-related excess accounted for 3944 (22%) of 17 536 deaths in older men, 1565 (33%) of 4751 deaths in women aged 15–54 years and 1493 (12%) of 12 302 deaths in older women.
For sensitivity analyses, alcohol use was crudely split into lower (<one bottle per week, including never drinkers) and higher usual consumption categories, and the analyses of tables 4 and 5 were then repeated. With this crude split, the uncorrected dose-related excess for alcohol poisoning was only 72% (1466/2048), but correction (as in tables 4 and 5) automatically increased this to 100%, and made dose-related excess mortality at ages 15–54 years 50% (7045/13 968) for men and 27% (1305/4751) for women, and at ages 55–74 years made it 22% (3827/17 542) for men and 10% (1275/12 302) for women. These corrected percentages are similar to those shown in tables 4 and 5, and were not materially affected by finer stratification for potential confounders (amount smoked, year of death, years since death, marital status, relationship to informant, ethnicity, education, occupation, socioeconomic status, or recent change in socioeconomic status) or by inclusion in the controls of all cancers not strongly related to alcohol (data not shown).
Non-beverage alcohol use was strongly correlated with other alcohol use but, given vodka consumption, was no more common in those dying from strongly alcohol-related causes than in those dying from other causes. For men who died at ages 15–39 years and were drinkers of less than one, one to less than three, or three or more bottles of vodka (or equivalent) per week, the respective proportions of deaths with non-beverage alcohol use reported were 1% (18/1306), 6% (70/1106), and 20% (250/1257) for the strongly alcohol-related causes and 1% (3/313), 5% (8/168), and 28% (34/120) for the other causes. These findings suggest that for a given amount of ethanol consumption its source was not strongly predictive of cause of death. For women, the corresponding percentages were based on much smaller numbers: 2% (8/405), 6% (9/153) and 20% (38/192) for strongly alcohol-related causes and 0% (0/240), 0% (0/23) and 39% (9/23) for other causes, respectively.
Figure 2 shows the regional mortality trends (1990–2001) in mortality from all causes, from the main causes strongly associated with alcohol use in this study (approximately as in table 2), and from the other causes. Because of the changes in Russian death coding in 1999, the strongly alcohol-related causes had to include chronic heart disease and exclude liver cancer (see panel 2). In both sexes and all age-groups there was a much sharper increase during 1992–94 in mortality from the strongly alcohol-related causes than from other causes. Fluctuations in these alcohol-related causes were the main determinants of the large fluctuations in all-cause mortality in the study areas, particularly at ages 15–34 years and 35–54 years. Thus, at these ages, the ratio of mortality from the strongly alcohol-related causes to mortality from all other causes fluctuated sharply, and was at a maximum in 1994. This was true for the whole study region (figure 2) and for the individuals in our study (data not shown).
We found strong dose-response associations between alcohol consumption and mortality from accidents, violence, and several disease groupings. If these associations are mainly causal, then alcohol was responsible for more than half of all deaths in younger men (15–54 years) in our study areas during 1990–2001, and was a major cause of death in older men (55–74 years) and in women. Additionally, large fluctuations in mortality from alcohol-related diseases were major determinants of the extreme fluctuations in overall adult mortality after 1991, so the proportion of deaths caused by alcohol would be much greater in some years than in others.
Our study of residents in three industrial cities populated mainly by European Russians was large and population based. The interviewers were local physicians; therefore, few families refused to be interviewed and cooperation was generally good. Information was unavailable only when the address no longer existed or no family member was found there. This excludes deaths in families that subsequently moved, deaths of those who (perhaps partly because of alcohol) were isolated or without a registered address, and deaths of migrants to the study cities. Otherwise, selection bias is unlikely to have had any major affect on the results.
Cases were those adults who had died from causes we judged beforehand likely to be related to drinking or smoking, and controls were those who had died from other causes. This designation of controls was somewhat arbitrary, but is supported by the cancer results. The extensive epidemiological evidence on alcohol and cancer, as summarised by the WHO International Agency for Research on Cancer (IARC),19 shows that the only major types of cancer much affected by alcohol in men are those of the liver and upper aerodigestive tract. This evidence helps validate the case–control results from our study (table 2), which show a highly significant effect of alcohol on mortality from cancers of the liver and upper aerodigestive tract, but not from lung cancer or stomach cancer. Few women consumed more than three bottles of vodka (or equivalent) per week, but among those who did, the only conventionally significant excess cancer risks were for those of the liver and upper aerodigestive tract.
Use of deceased people as controls was intended to limit the effects of recall and reporting bias, with the expectation that there would be no large systematic bias between people with similar drinking habits who had died of different diseases. (Similarly, many epidemiological studies of hospitalised cases use hospitalised controls.) Although families in our study are likely to misreport alcohol consumption, we had hoped that such misreporting would merely dilute the strengths of any associations. We found, however, that under-reporting of moderate alcohol consumption was particularly common for those who had died from accidents, violence, and the diseases strongly related to drinking. This under-reporting could substantially distort relative risks comparing never-drinkers with reference drinkers, but should have less of an effect on the corrected dose-related excess, on which our main conclusions are based. Moreover, sensitivity analyses that combined never-drinkers with the lowest two groups of ever-drinkers yielded similar corrected estimates of excess mortality. To include a reasonably representative sample of all deaths, including those of alcoholics, we settled for the imperfect, and potentially slightly biased, exposure information that families can provide. It is only because the effects of alcohol on mortality in Russia are so great that our crude methods can provide useful estimates of them; in less severely affected populations such methods might not yield useful results.
For those who died before the age of 40 years, we asked about regular non-beverage alcohol use. Such practice was common only in the highest alcoholic beverage consumption category, and was not independently predictive of risk. Thus, as others have suggested,20 non-beverage alcohol use should perhaps be seen mainly as a source of ethanol rather than of other toxins.
Apart from liver cancer and upper aerodigestive cancer, the strongly positive associations were with mortality (in both men and women) from liver disease, pancreatic disease, tuberculosis, pneumonia, ill-specified disease, acute IHD other than myocardial infarction, and external causes (alcohol poisoning, accidents, and violence). At ages 15–54 years, these strongly positive associations accounted for a substantial proportion of all deaths (figure 2), and for about 90% of the excess mortality (tables 4 and 5); vascular disease accounted for most of the remainder. The only significantly inverse association was with mortality from breast cancer, which was substantially lower in the few women in the highest alcohol category (mean more than five bottles of vodka or equivalent per week) than in women from the lower alcohol consumption categories. In other populations, moderate alcohol consumption (all levels of which would be within our reference category) appears to increase the incidence of breast cancer.19,21 The reasons for this apparent discrepancy are unclear, because information on many other potentially relevant factors was unavailable; however, the inverse association with breast cancer would, even if causal, account for only 0·1% of all deaths.
The excess mortality from liver cancer, upper aerodigestive cancer, liver disease, and pancreatic disease is largely or wholly because alcohol caused the disease that caused death.19,22–27 The excess mortality from tuberculosis and pneumonia may be partly a result of increased exposure to infection, reduced immunocompetence, or decreased likelihood of cure;28,29 in each case, however, alcohol use could be a direct or indirect cause of the excess. Some of the excess mortality from stroke and other vascular diseases must reflect the ability of alcohol to increase blood pressure.
The relative risks for mortality from ill-specified diseases were particularly extreme, perhaps partly because alcohol use was associated with inadequate post-mortem assessment of causes. The largest single contributor to the alcohol-associated excess mortality from disease was acute IHD other than myocardial infarction. In a survey of forensic autopsies in Barnaul during 1990–2004 at which post-mortem blood alcohol was recorded, half of those who died aged 15–69 years with non-myocardial infarction acute IHD (ICD-10 code I24) as the certified cause did not have raised blood alcohol concentrations, but 15% had concentrations over 4 g/L, which is potentially lethal.6 In other populations, unspecified ICD codes could usually, with better data, be reassigned to more specific codes in the same disease group.30 In Russia, however, unspecified cardiovascular disease codes are common, and probably mask large numbers of deaths from acute alcohol poisoning or from acute outcomes of chronic alcoholic cardiotoxicity. This hypothesis is strongly supported by the sharp fluctuations in some but not all vascular causes of death during 1990–2006 in Russia as a whole; in men aged 35–69 years there was little variation in the national mortality attributed to acute myocardial infarction, but there was extreme variation in the much greater mortality attributed to other acute IHD, with a large increase after 1991 that peaked sharply in 1994.6
The largest contributors to alcohol-associated excess mortality were accidents and violence (including assault and suicide). The excess of accidental deaths in alcohol users could be largely or wholly causal. The excess of deaths from violence by others could be partly from the effects of alcohol on the behaviour of the dead person and partly from exposure to other drinkers. (Fluctuations in population alcohol consumption match those in population homicide rates.31) Finally, alcohol can cause depression,22 impulsivity, and suicidal behaviour,24,32 and many people who committed suicide had raised blood ethanol concentrations.6 The relative risks for death from assault and suicide were both so extreme in the highest male and two highest female alcohol consumption categories that most of the excess must be causal.32
A case–control study with live controls estimated that 43% of all deaths in men aged 25–54 years in Izhevsk in 2003–05 were from alcohol (including non-beverage alcohol).14 Our study (after correction to include all deaths from alcohol poisoning) attributed to alcohol 59% of all male and 33% of all female study deaths at ages 15–54 years; and, our corrected percentages might still underestimate the alcohol-attributable proportion of all deaths in the study areas, since they were calculated only for non-migrants with families still available at the same address years later, and exclude some deaths due to alcohol use by others. Moreover, they average the whole study period (1990–2001); alcohol-attributable proportions would have been greater in the central years (1993–97) than in 1990–91 or 1998–99, since the large temporal fluctuations in overall mortality (and, in particular, the large increase during 1992–93) were mainly caused by sudden large changes in the causes we found to be strongly associated with alcohol (figure 2).
For adult mortality in Russia as a whole, the large fluctuations since 1990 (with, again, a particularly sharp increase during 1992–93) were due to much the same causes as the fluctuations in our study area;6 therefore, the proportion of adult Russian mortality caused by alcohol must, as in our study, have been large and have varied greatly (figures 1 and 2).
Figure 3 compares the all-cause mortality rates (averaging male and female) at ages 15–54 years in Russia and western Europe since 1980. Because our study, and other studies of individuals,11–14 show alcohol to have been a major determinant of overall mortality in Russia, the sharp changes in alcohol and in mortality in the mid-1980s are particularly informative, and they are well documented3–8 and uncomplicated by the social upheavals of later decades. Because of the restrictions suddenly placed on alcohol in mid-1985, total consumption (legal plus other) dropped suddenly by about a quarter,7,8 as did overall mortality at ages 15–54 years (figures 1 and 3). Still, however, during the period of lowest alcohol consumption (1986–87), about three-quarters of pre-1985 consumption remained.7 Thus, although Russian mortality was then at its lowest, a great deal of the alcohol-attributable mortality must also have remained.8 If, therefore, the 1985 decrease of only about a quarter in alcohol consumption was largely responsible for the 1984–86 decrease of almost a quarter in Russian mortality at ages 15–54 years, then in the (hypothetical) absence of all deaths from alcohol, Russian and west European death rates at these ages could well have been similar in 1986. This suggests that, in Russia, alcohol has been of even greater importance than tobacco as a cause of premature death. In western Europe in the mid-1980s, smoking was responsible for about a quarter of all mortality (and a third of all male mortality) in middle age, and in Russia male lung cancer mortality was then about 50% greater than in western Europe.1–3,33,34 Even if the overall mortality rate from smoking was also somewhat greater in Russia, however, it would still have been much smaller, at least at ages 15–54 years, than the probable effects of alcohol in Russia since 1991 (figures 1 and 3).
If, without alcohol, mortality at these ages would have been similar in Russia and western Europe in the mid-1980s, then (without alcohol in either population) it would probably still be similar in the present decade. If so, then Russian death rates at these ages would now be much less than double the corresponding rates in western Europe (figure 3). The actual Russian mortality rate in people aged 15–54 years in 2006 was, however, more than five times (for men) and three times (for women) the rate in western Europe (figure 1).1–3 This large discrepancy is consistent with alcohol being responsible in the current decade for about three-quarters of all male Russian deaths at ages 15–54 years and about half of all female Russian deaths at these ages—ie, proportions even greater than in our study population. Whatever the exact alcohol-attributed proportion may have been at particular times since 1980, however, it was always high, has fluctuated greatly, and is still high.
We conclude that alcohol is the main cause (and perhaps the only major cause) of the large fluctuations in Russian adult mortality since 1980, and that alcohol and tobacco account for most or all of the large difference in premature adult mortality between Russia and western Europe.
DZ, RP, PBo, and PBr designed the study, DZ and AB coordinated its conduct, RK, AL, IK, VI, and TT coordinated the fieldwork, AB and JB prepared the final database, JB and RP undertook the statistical analyses, and DZ, RP, and PBr drafted the manuscript. All authors contributed to the final paper.
Conflicts of interest
We declare that we have no conflicts of interest.
This study is funded by CTSU core support from the UK Medical Research Council, Cancer Research UK, and British Heart Foundation, IARC collaborative research agreements (GEE/07/05 & GEP/08/07), and EC D-G for Research (grants ICA2-1999-10139 & ICA2-CT-2001-10002). We thank the field workers for their help and the interviewees for their cooperation.
|1.||WHOWHO statistical information system (WHOSIS). 2007World Health Organization; Geneva: http://www.who.int/whosis/en (accessed April 23, 2009).|
|2.||United Nations Population DivisionWorld population prospects (2004 revision: ST/ESA/SER.A/244). 2005United Nations; New York:|
|3.||Peto R,Watt J,Boreham J. Deaths from smokinghttp://www.ctsu.ox.ac.uk/deathsfromsmoking/ (accessed June 5, 2009).|
|4.||Shkolnikov V,McKee M,Leon DA. Changes in life expectancy in Russia in the mid-1990sLancet 2001;357:917–921. [pmid: 11289348]|
|5.||Men T,Brennan H,Boffetta H,Zaridze D. Russian mortality trends since 1991; analysis by cause and regionBMJ 2003;327:964–969. [pmid: 14576248]|
|6.||Zaridze D,Maximovitch D,Lazarev A. Alcohol poisoning is a main determinant of recent mortality trends in Russia: evidence from a detailed analysis of mortality statistics and autopsiesInt J Epidemiol 2009;38:143–153. [pmid: 18775875]|
|7.||Nemtsov AV. Estimates of total alcohol consumption in Russia, 1980–1994Drug Alcohol Depend 2000;58:133–142. [pmid: 10669064]|
|8.||Nemtsov AV. Alcohol-related human losses in Russia in the 1980s and 1990sAddiction 2002;97:1413–1425. [pmid: 12410782]|
|9.||Leon DA,Chenet L,Shkolnikov VM. Huge variation in Russian mortality rates 1984–1994: artefact, alcohol, or what?Lancet 1997;350:383–388. [pmid: 9259651]|
|10.||McKee M,Shkolnikov V,Leon DA. Alcohol is implicated in the fluctuations in cardiovascular diseases in Russia since the 1980sAnn Epidemiol 2001;11:1–6. [pmid: 11164113]|
|11.||Shestov DB,Deev AD,Klimov AN,Davis CE,Tyroler HA. Increased risk of coronary heart disease death in men with low total and low-density lipoprotein cholesterol in Russian Lipid Research Clinics Prevalence Follow-up StudyCirculation 1993;88:846–853. [pmid: 8353914]|
|12.||Malyutina S,Bobak M,Kurilovitch S. Relation between heavy and binge drinking and all-cause and cardiovascular mortality in Novosibirsk, Russia: a prospective cohort studyLancet 2002;360:1448–1454. [pmid: 12433511]|
|13.||Nickolson A,Bobak M,Murphy M,Rose R,Marmot M. Alcohol consumption and increased mortality in Russian men and women: a cohort study based on the mortality of relativesBull World Health Organ 2005;83:812–819. [pmid: 16302037]|
|14.||Leon DA,Saburova L,Tomkins S. Hazardous alcohol drinking and premature mortality in Russia: a population based case-control studyLancet 2007;369:2001–2009. [pmid: 17574092]|
|15.||Shkolnikov V,Chervyakov VV,McKee M,Leon DA. Russian mortality beyond vital statistics: effect of social status and behaviours on death from circulatory diseases and external causes: a case-control study of men aged 20–55 years in Udmuntia, 1998–99Demogr Res 2004;S2:71–104.|
|16.||Walberg P,McKee M,Shkolnikov V,Chenet L,Leon DA. Economic change, crime, and mortality crisis in Russia: regional analysisBMJ 1998;317:312–318. [pmid: 9685275]|
|17.||Stuckler D,King L,McKee M. Mass privatisation and the post-communist mortality crisis: a cross-national analysisLancet 2009;373:399–407. [pmid: 19150132]|
|18.||WHOInternational classification of diseases and related health problems, 10th revision (ICD-10). 1992World Health Organization; Geneva:|
|19.||IARCIARC monographs on the evaluation of carcinogenic risk to humans. Volume 44, alcohol drinking. 1988International Agency for Research on Cancer; Lyon:|
|20.||McKee M,Suzcs S,Sarvary A. The composition of surrogate alcohols consumed in RussiaAlcohol Clin Exp Res 2005;29:1884–1888. [pmid: 16269919]|
|21.||Allen T,Beral V,Casabonne B. Moderate alcohol intake and cancer incidence in womenJ Natl Cancer Inst 2009;101:282–283. [pmid: 19244170]|
|22.||Rehm J,Room R,Monteiro M. Alcohol useEzzati M,Lopez AD,Rodgers A,Murray CJLComparative quantification of health risks: global and regional burden of disease attributable to selected major risk factors 2004World Health Organization; Geneva: :959–1108.|
|23.||Rehm J,Room R,Graham K,Monteiro M,Gmel G,Sempos CJ. The relationship of average volume of alcohol consumption and patterns of drinking to burden of diseaseAddiction 2003;98:1209–1228. [pmid: 12930209]|
|24.||Schuckit MA. Alcohol-use disordersLancet 2009;373:492–501. [pmid: 19168210]|
|25.||Hatton J,Burton A,Nash H,Munn E,Burgoyne L,Sheron N. Drinking patterns, dependency and life-time drinking history in alcohol-related liver diseaseAddiction 2009;104:603–611. [pmid: 19215601]|
|26.||Mathurin P,Deltenre P. Effect of binge drinking on the liver: an alarming public health issue?Gut 2009;58:613–617. [pmid: 19174416]|
|27.||Kristiansen L,Gronback M,Becker U,Tolstrup JS. Risk of pancreatitis according to alcohol drinking habits: a population based cohort studyAm J Epidemiol 2008;168:932–937. [pmid: 18779386]|
|28.||Lonnroth K,Williams B,Stadlin S,Jaramillo E,Dye C. Alcohol use as a risk factor for tuberculosis: a systematic reviewBMC Public Health 2008;8:289. [pmid: 18702821]|
|29.||Fernández-Solá J,Junqué A,Estruch R,Monforte R,Torres A,Urbano-Márquez A. High alcohol intake as a risk and prognostic factor for community aquired pneumoniaArch Intern Med 1995;155:1649–1654. [pmid: 7618989]|
|30.||Rehm J. Commentary: alcohol poisoning in Russia: implication for monitoring and comparative risk assessmentInt J Epidemiol 2009;38:154–155. [pmid: 18824468]|
|31.||Pridemore WA. Vodka and violence: alcohol consumption and homicide rates in RussiaAm J Public Health 2002;92:1921–1930. [pmid: 12453810]|
|32.||Sher L. Alcohol consumption and suicideQJM 2006;99:57–61. [pmid: 16287907]|
|33.||Peto R,Lopez AD,Boreham J,Thun M,Heath C. Mortality from tobacco in developed countries: indirect estimation from national vital statisticsLancet 1992;339:1268–1278. [pmid: 1349675]|
|34.||Zaridze D,Peto RTobacco: a major international health hazard. IARC scientific publication no 74. 1986WHO International Agency for Research on Cancer; Lyon:|
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