| Alcohol abuse and brain infarction. | |
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MedLine Citation:
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PMID: 2291843 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent findings on the relation between alcohol abuse and ischaemic brain infarction are reviewed. Much of the association has hitherto been explained by the effects of confounding factors such as smoking. Alcohol increases blood pressure in both hypertensive and normotensive subjects and alcohol induced hypertension enhances the risk of both hemorrhagic and ischaemic strokes. Analysis of case histories shows that alcohol abuse has precipitated cerebral embolism in conjunction with cardiac diseases including alcoholic cardiomyopathy and paradoxical embolism due to deep vein thrombosis via atrial septal defect. Among young adults, falling when intoxicated with alcohol has caused traumatic dissection of the carotid artery and consequent brain infarction. Alcohol may predispose individuals to cerebral embolism, thrombosis and ischaemia via its effects on the coagulation cascade, platelet count and function and contractility of the cerebral vessels. Further studies are needed to prove that these mechanisms are significant and to identify any other mechanisms which may mediate the risk associated with alcohol abuse. On the basis of current data, alcohol should be considered as an independent risk factor for ischaemic cerebral infarction in young adults. |
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Authors:
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M Hillbom; M Kaste |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Annals of medicine Volume: 22 ISSN: 0785-3890 ISO Abbreviation: Ann. Med. Publication Date: 1990 |
Date Detail:
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Created Date: 1991-04-10 Completed Date: 1991-04-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8906388 Medline TA: Ann Med Country: FINLAND |
Other Details:
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Languages: eng Pagination: 347-52 Citation Subset: IM |
Affiliation:
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Department of Neurology, University of Helsinki, Finland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alcohol Drinking Alcoholism / complications*, physiopathology Cerebral Infarction / etiology* Confounding Factors (Epidemiology) Ethanol / pharmacology Humans |
| Chemical | |
Reg. No./Substance:
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64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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