Document Detail


Alcohol and HIV disease progression: weighing the evidence.
MedLine Citation:
PMID:  20814765     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Heavy alcohol use is commonplace among HIV-infected individuals; however, the extent that alcohol use adversely impacts HIV disease progression has not been fully elucidated. Fairly strong evidence suggests that heavy alcohol consumption results in behavioral and biological processes that likely increase HIV disease progression, and experimental evidence of the biological effect of heavy alcohol on simian immunodeficiency virus in macaques is quite suggestive. However, several observational studies of the effect of heavy alcohol consumption on HIV progression conducted in the 1990s found no association of heavy alcohol consumption with time to AIDS diagnosis, while some more recent studies showed associations of heavy alcohol consumption with declines of CD4 cell counts and nonsuppression of HIV viral load. We discuss several plausible biological and behavioral mechanisms by which alcohol may cause HIV disease progression, evidence from prospective observational human studies, and suggest future research to further illuminate this important issue.
Authors:
Judith A Hahn; Jeffrey H Samet
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current HIV/AIDS reports     Volume:  7     ISSN:  1548-3576     ISO Abbreviation:  Curr HIV/AIDS Rep     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-09-14     Completed Date:  2011-01-11     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  101235661     Medline TA:  Curr HIV/AIDS Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  226-33     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acquired Immunodeficiency Syndrome / immunology,  physiopathology*,  virology
Alcohol Drinking*
Alcoholism / complications*
Anti-HIV Agents / therapeutic use
Behavior, Addictive
CD4 Lymphocyte Count
Disease Progression*
Disease Susceptibility
HIV / physiology
HIV Infections / drug therapy,  immunology,  physiopathology*,  virology
Health Behavior
Humans
Liver Diseases / complications
Malnutrition / complications
Patient Compliance
Risk-Taking
Viral Load
Grant Support
ID/Acronym/Agency:
K24 AA015674/AA/NIAAA NIH HHS; K24 AA015674-04/AA/NIAAA NIH HHS
Chemical
Reg. No./Substance:
0/Anti-HIV Agents
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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