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Alcohol Effects on the P2 component of Auditory Evoked Potentials.
MedLine Citation:
PMID:  24519012     Owner:  NLM     Status:  Publisher    
This is a second part of a research aimed to study the effects of alcohol on the electrophysiological processes in student volunteers. The first part showed that alcohol slowed the Omitted Stimulus Potential (OSP). This work studied the ethanol effects on the parameters (i.e. rate of rise, amplitude and peak latency) of the P2 component of the evoked potentials (EPs) yielded by trains of auditory stimuli. It is hypothesized here that if P2 and OSP waves share some common neural processes then alcohol should also affect these specific parameters. A dose of 0.8 g/kg of alcohol or a placebo (0 g/kg) was administered to two groups of 15 young men who were tested before and again after treatment. The pre-post treatment change in each of the measurements was used to assess the treatment effects. The results showed that compared to placebo, alcohol slowed the P2 rise rate and reduced its amplitude, with no effects on peak latency. The rise rate is more sensitive to alcohol but more resistant to the adaptation process. Alcohol resembles the response inhibition model acting against the adaptation. The rise rate of the P2 and the OSP waves are affected by alcohol in a similar fashion, suggesting similar neural generative mechanisms.
Oscar H Hernández; Rolando García-Martínez; Víctor Monteón; Claudinei C Gomes
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-1-29
Journal Detail:
Title:  Anais da Academia Brasileira de Ciencias     Volume:  0     ISSN:  1678-2690     ISO Abbreviation:  An. Acad. Bras. Cienc.     Publication Date:  2014 Jan 
Date Detail:
Created Date:  2014-2-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7503280     Medline TA:  An Acad Bras Cienc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  0     Citation Subset:  -    
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