Document Detail

Alcohol drinking status is associated with serum high molecular weight adiponectin in community-dwelling Japanese men.
MedLine Citation:
PMID:  20805635     Owner:  NLM     Status:  MEDLINE    
AIM: Serum high molecular weight (HMW) adiponectin improves insulin sensitivity, and a decreased level of serum HMW adiponectin has been reported as a risk factor for the development of diabetes and coronary heart disease. This association may be further confounded by the alcohol drinking status, which is involved in the development of liver dysfunction. The aim of this study was to determine whether the alcohol drinking status is associated with serum HMW adiponectin levels in community-dwelling Japanese men.
METHODS: A cross-sectional study was carried out in 2002. Study participants without a clinical history of diabetes (747 men aged 60 ± 14 (mean ± standard deviation) (range, 20-89) years) were randomly recruited from a single community at the time of their annual health examination. They were classified into never drinkers, light drinkers (< 1 unit/day), moderate drinkers (1-1.9 units/day), and heavy drinkers (≥ 2 units/day). We examined the effects of alcohol consumption on serum HMW adiponectin.
RESULTS: Overall, mean serum HMW adiponectin levels were significantly lower in the group with higher alcohol consumption, and there were inter-group differences in the alcohol drinking status. Moreover, age-adjusted mean serum HMW adiponectin levels were significantly lower in the group with higher alcohol consumption. Multiple linear regression analysis showed that the alcohol drinking status was significantly and independently associated with serum adiponectin as well as age, smoking status, TG, HDL-C, LDL-C, serum ALT, and HOMA-IR. Multivariate-adjusted mean serum HMW adiponectin levels were also significantly lower in the group with higher alcohol consumption.
CONCLUSION: The alcohol drinking status is negatively associated with serum HMW adiponectin levels in Japanese community-dwelling men.
Ryuichi Kawamoto; Yasuharu Tabara; Katsuhiko Kohara; Tetsuro Miki; Nobuyuki Ohtsuka; Tomo Kusunoki; Masanori Abe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-08-26
Journal Detail:
Title:  Journal of atherosclerosis and thrombosis     Volume:  17     ISSN:  1880-3873     ISO Abbreviation:  J. Atheroscler. Thromb.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-10-06     Completed Date:  2011-02-03     Revised Date:  2012-04-09    
Medline Journal Info:
Nlm Unique ID:  9506298     Medline TA:  J Atheroscler Thromb     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  953-62     Citation Subset:  IM    
Department of Community Medicine, Ehime University Graduate School of Medicine, Ehime, Japan.
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MeSH Terms
Adiponectin / blood,  chemistry
Aged, 80 and over
Alcohol Drinking / adverse effects,  blood*
Asian Continental Ancestry Group
Biological Markers / blood
Cardiovascular Diseases / blood,  etiology
Cross-Sectional Studies
Insulin Resistance / physiology
Linear Models
Liver Diseases, Alcoholic / blood,  etiology
Metabolic Syndrome X / blood,  etiology
Middle Aged
Molecular Weight
Risk Factors
Young Adult
Reg. No./Substance:
0/ADIPOQ protein, human; 0/Adiponectin; 0/Biological Markers

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