Document Detail

Alcohol and B1 vitamin deficiency-related stillbirths.
MedLine Citation:
PMID:  19530005     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The present study attempts to determine whether prenatal thiamine (B1 vitamin) deficiency and prenatal alcohol exposure are risk factors for stillbirths. METHODS: From conception to parturition, Wistar rat dams were exposed to the following treatments: (1) Rat dams consuming a thiamine-deficient diet; (2) 12% alcohol/water drinking mothers; (3) mothers drinking 12% alcohol/water + thiamine hydrochloride mixture. Appropriate pair-fed controls and ad libitum controls were assessed. Gestation outcome and fetal parameters, including spontaneous abortion, still-born fetuses, litter size and birth weight, were assessed from the dams of each experimental group. RESULTS: Both alcohol and thiamine deficiency during pregnancy increased fetal death (48.26%vs. 84.47%), reduced litter size (44.54%vs. 72.7%), respectively, and lowered birth weight. Thiamine administration reversed the effects of alcohol-induced fetal death, suggesting that a part of deleterious actions of alcohol on fetal death was mediated by thiamine deficiency. Prenatal thiamine deficiency increased singularly spontaneous abortion with abundant bleeding (40%), rising the occurrence of stillbirth. Such a pathology was not observed in alcohol group. CONCLUSIONS: The results indexed thiamine deficiency as a potent risk factor for stillbirths. The vitamin supply during pregnancy prevents stillbirths related to chronic alcoholism and different facets of malnutrition.
Abdoulaye Bâ
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  22     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-06-16     Completed Date:  2009-08-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  452-7     Citation Subset:  IM    
Universite de Cocody, UFR Biosciences, Côte d'Ivoire.
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MeSH Terms
Abortion, Spontaneous / epidemiology,  etiology
Alcohol Drinking / adverse effects*
Animals, Newborn
Birth Weight / drug effects
Ethanol / adverse effects,  pharmacology
Pregnancy Complications / blood,  epidemiology,  etiology*,  pathology
Rats, Wistar
Risk Factors
Thiamine / blood
Thiamine Deficiency / blood,  complications*,  epidemiology,  pathology
Reg. No./Substance:
59-43-8/Thiamine; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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