Document Detail

Albuterol extended-release products: a comparison of steady-state pharmacokinetics.
MedLine Citation:
PMID:  2052468     Owner:  NLM     Status:  MEDLINE    
A new extended-release formulation of albuterol, Volmax, was developed based on the oral osmotic drug delivery system. Proventil Repetabs, another extended-release formulation of albuterol, is a repeat-action tablet. The steady-state pharmacokinetic profile of Volmax 8 mg orally every 12 hours for 3 days was compared with that of Proventil Repetabs 8 mg orally every 12 hours for 3 days in a randomized, two-way, crossover study in 23 healthy men. Results were determined for both daytime and nighttime dosing intervals. Volmax demonstrated significantly less peak-trough fluctuation during both dosing intervals than Proventil Repetabs (p less than 0.05). Peak plasma concentrations were higher and occurred earlier with Proventil Repetabs. There were no significant differences between the two formulations with respect to reported adverse experiences. Volmax exhibited a more controlled release of albuterol during both daytime and nighttime dosing intervals than Proventil Repetabs.
E K Hussey; K H Donn; J R Powell
Related Documents :
19035878 - Effects of resveratrol on the pharmacokinetics of diltiazem and its major metabolite, d...
21320758 - Low doses of dextromethorphan attenuate morphine-induced rewarding via the sigma-1 rece...
16572918 - Comparative study on the bioequivalence of two different gabapentin formulations. a ran...
4005128 - Oros controlled-release formulations of metoprolol: an approach to the development of a...
16005148 - Optimization of the aerobic biological treatment of thermophilically treated refractory...
7462918 - Effect of patulin on hepatic monooxygenase in male mice.
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pharmacotherapy     Volume:  11     ISSN:  0277-0008     ISO Abbreviation:  Pharmacotherapy     Publication Date:  1991  
Date Detail:
Created Date:  1991-07-19     Completed Date:  1991-07-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8111305     Medline TA:  Pharmacotherapy     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  131-5     Citation Subset:  IM    
Clinical Pharmacokinetics Department, Glaxo Inc., Research Triangle Park, North Carolina 27709.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Administration, Oral
Albuterol / administration & dosage,  pharmacokinetics*
Delayed-Action Preparations
Drug Administration Schedule
Reg. No./Substance:
0/Delayed-Action Preparations; 0/Tablets; 18559-94-9/Albuterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Treatment of essential hypertension in Asians: enalapril as monotherapy versus combination therapy w...
Next Document:  Pharmacologic treatment of primary and secondary pulmonary hypertension.