Document Detail


Albuterol extended-release products: a comparison of steady-state pharmacokinetics.
MedLine Citation:
PMID:  2052468     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A new extended-release formulation of albuterol, Volmax, was developed based on the oral osmotic drug delivery system. Proventil Repetabs, another extended-release formulation of albuterol, is a repeat-action tablet. The steady-state pharmacokinetic profile of Volmax 8 mg orally every 12 hours for 3 days was compared with that of Proventil Repetabs 8 mg orally every 12 hours for 3 days in a randomized, two-way, crossover study in 23 healthy men. Results were determined for both daytime and nighttime dosing intervals. Volmax demonstrated significantly less peak-trough fluctuation during both dosing intervals than Proventil Repetabs (p less than 0.05). Peak plasma concentrations were higher and occurred earlier with Proventil Repetabs. There were no significant differences between the two formulations with respect to reported adverse experiences. Volmax exhibited a more controlled release of albuterol during both daytime and nighttime dosing intervals than Proventil Repetabs.
Authors:
E K Hussey; K H Donn; J R Powell
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pharmacotherapy     Volume:  11     ISSN:  0277-0008     ISO Abbreviation:  Pharmacotherapy     Publication Date:  1991  
Date Detail:
Created Date:  1991-07-19     Completed Date:  1991-07-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8111305     Medline TA:  Pharmacotherapy     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  131-5     Citation Subset:  IM    
Affiliation:
Clinical Pharmacokinetics Department, Glaxo Inc., Research Triangle Park, North Carolina 27709.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adolescent
Adult
Albuterol / administration & dosage,  pharmacokinetics*
Delayed-Action Preparations
Drug Administration Schedule
Humans
Male
Tablets
Chemical
Reg. No./Substance:
0/Delayed-Action Preparations; 0/Tablets; 18559-94-9/Albuterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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