Document Detail

Albuterol and exercise effects on ankle extensor strength during 40 days of unloading.
MedLine Citation:
PMID:  18581941     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: In-flight ankle extensor (AEXT) strength losses are an impediment to long-term space travel. The current study examines if albuterol helps resistance exercise (RE) abate AEXT strength loss incurred over a 40-d unloading period. METHODS: All subjects (21 men, M; 15 women, W) performed unilateral limb suspension (ULLS) and exercised on a flywheel ergometer (FERG) with their otherwise unloaded AEXT. With a double-blind randomization assignment, subjects either received placebo (PLA, lactose) or albuterol (ALB, 16 mg x d(-1)) via four daily capsule doses with no crossover. FERG calf press workouts done 3 d x wk(-1) provided concentric and eccentric total work (CTW, ETW) and average power (CAP, EAP) measures. Workout data from the 40-d period were averaged and partitioned into four consecutive 10-d periods. Data were compared with a 2 (gender) x 2 (treatment) x 4 (time) MANCOVA, with day 0 AEXT strength measurements and a drug/body mass ratio as covariates. RESULTS: CTW and ETW days 11-20, 21-30, and 31-40, as well as CAP and EAP days 11-20 and 21-30 showed the following significant results: ALB-W > ALB-M, PLA-M > PLA-W. CAP and EAP days 31-40 showed the following significant results: ALB-W, ALB-M, PLA-M > PLA-W. DISCUSSION: The combined RE-albuterol treatment most likely evoked unloaded AEXT strength gains in women due to heightened myofibril sensitivity for Ca+2. Despite a drug/body mass covariate, gender-related differences should be interpreted with caution. Future work should compare absolute and relative beta2 agonist dosages on gender-related muscle mass and strength changes.
John F Caruso; John L Hamill; Miki Yamauchi; Tim D Cook; Dean R Mercado; Eric E Wickel
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Aviation, space, and environmental medicine     Volume:  79     ISSN:  0095-6562     ISO Abbreviation:  Aviat Space Environ Med     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-27     Completed Date:  2008-07-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7501714     Medline TA:  Aviat Space Environ Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  577-84     Citation Subset:  IM; S    
Exercise and Sports Science Program, The University of Tulsa, Tulsa OK, USA.
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MeSH Terms
Adrenergic beta-Agonists / therapeutic use*
Albuterol / therapeutic use*
Ankle / physiology
Muscle Strength / drug effects*
Muscle Weakness / prevention & control*
Muscle, Skeletal / drug effects
Sex Factors
Weightlessness Countermeasures*
Reg. No./Substance:
0/Adrenergic beta-Agonists; 18559-94-9/Albuterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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