Document Detail

Albuterol delivery during noninvasive ventilation.
MedLine Citation:
PMID:  16318646     Owner:  NLM     Status:  MEDLINE    
HYPOTHESIS: Albuterol delivered during noninvasive positive-pressure ventilation is affected by use of a nebulizer or metered-dose inhaler (MDI) and whether the leak port is in the hose or the mask. METHODS: A lung model that simulated spontaneous breathing at 20 breaths/min was used. A bi-level positive-airway-pressure ventilator (Respironics S/T30) was set for an inspiratory positive airway pressure of 15 cm H(2)O and an expiratory positive airway pressure of 5 cm H(2)O. The tidal volume delivered was 0.4 L. Two mask types were used: one in which the leak port was incorporated into the circuit, and another in which the leak port was incorporated into the mask. The nebulizer was filled with 4 mL, which contained 5 mg of albuterol, connected via a T-piece directly to the mask, and operated at 8 L/min for 15 min. For the MDI studies, a spacer was placed between the mask and the circuit, and an MDI was actuated into the spacer, either synchronized with the initiation of inhalation or during the exhalation phase (4 actuations separated by \G 15 s in each case). Albuterol was washed from the filter and measured with ultraviolet spectrophotometry. RESULTS: With the nebulizer, significantly more albuterol was delivered to the filter when the leak port was in the circuit (p = 0.001). Significantly more albuterol was delivered with the nebulizer than with the MDI (p < 0.001). The efficiency of albuterol delivery (percent delivered) was similar for nebulizer and MDI with the leak port in the circuit (p = 0.57), but better with the MDI with the leak port in the mask (p = 0.001). Albuterol delivery was significantly less when the MDI was actuated during exhalation (p = 0.001). CONCLUSIONS: Albuterol delivery with noninvasive positive-pressure ventilation was affected by the type of aerosol delivery device, by the location of the leak port, and by actuating the MDI at the proper time in the respiratory cycle.
Matthew P Branconnier; Dean R Hess
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Respiratory care     Volume:  50     ISSN:  0020-1324     ISO Abbreviation:  Respir Care     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-12-01     Completed Date:  2006-02-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7510357     Medline TA:  Respir Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1649-53     Citation Subset:  IM    
Department of Respiratory Care, Massachusetts General Hospital, Boston, 02114, USA.
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MeSH Terms
Administration, Inhalation
Albuterol / administration & dosage*
Bronchodilator Agents / administration & dosage*
Equipment Design
Metered Dose Inhalers*
Models, Biological
Nebulizers and Vaporizers*
Positive-Pressure Respiration / instrumentation*
Reg. No./Substance:
0/Bronchodilator Agents; 18559-94-9/Albuterol
Comment In:
Respir Care. 2005 Dec;50(12):1621-2   [PMID:  16318642 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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