| Albuminuria and insulin resistance in children with biopsy proven non-alcoholic fatty liver disease. | |
| | |
MedLine Citation:
|
PMID: 19242728 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Insulin resistance may favor increased urinary albumin excretion (UAE), leading progressively to chronic kidney disease (CKD). A recent study on non-alcoholic fatty liver disease (NAFLD), a condition of insulin resistance, associated this disease with the incidence of CKD in patients with type 2 diabetes. The aim of our study was to determine whether there is an association between insulin resistance and kidney function, based on estimates of UAE and creatinine clearance in children with biopsy-proven NAFLD. Kidney function was assessed in 80 patients with NAFLD and 59 individuals of normal weight matched for age and sex. Insulin resistance was measured by means of the homeostatic model assessment-insulin resistance (HOMA-IR) and limited to NAFLD patients by using the whole-body insulin sensitivity index. The HOMA-IR was found to differ significantly between the two groups (2.69 +/- 1.7 vs. 1.05 +/- 0.45; p = 0.002), while UAE (9.02 +/- 5.8 vs. 8.0 +/- 4.3 mg/24 h; p = 0.9) and creatinine clearance (78 +/- 24 vs. 80 +/- 29 mg/min; p = 0.8) did not. We found a significant but weak inverse correlation between insulin sensitivity and creatinine clearance in NAFLD patients (r (s) = -0.25;p = 0.02). No difference was observed in kidney function between NAFLD children presenting with or without metabolic syndrome, low or normal HDL-cholesterol, and different degrees of histological liver damage (grade of steatosis >or=2, necro-inflammation, and fibrosis). Patients with hypertension had increased levels of UAE (p = 0.04). A longer exposure to insulin resistance may be required to cause the increase in urinary albumin excretion and to enable the detection of the effect of the accelerated atherogenic process most likely occurring in children with fatty liver disease. Longitudinal studies are needed to rule out any causative relationship between insulin resistance and urinary albumin excretion. |
| | |
Authors:
|
Melania Manco; Paolo Ciampalini; Rita DeVito; Andrea Vania; Marco Cappa; Valerio Nobili |
Publication Detail:
|
Type: Journal Article Date: 2009-02-26 |
Journal Detail:
|
Title: Pediatric nephrology (Berlin, Germany) Volume: 24 ISSN: 1432-198X ISO Abbreviation: Pediatr. Nephrol. Publication Date: 2009 Jun |
Date Detail:
|
Created Date: 2009-07-02 Completed Date: 2009-09-14 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8708728 Medline TA: Pediatr Nephrol Country: Germany |
Other Details:
|
Languages: eng Pagination: 1211-7 Citation Subset: IM |
Affiliation:
|
Scientific Directorate, Bambino Gesù Hospital, Research Institute IRCCS, 00165, Rome, Italy. melaniamanco@tiscali.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Albuminuria
/
complications*,
genetics,
pathology* Biopsy Blood Glucose / genetics Body Mass Index Case-Control Studies Child Cholesterol, HDL / genetics Creatinine / blood, urine Fatty Liver / complications*, metabolism, pathology* Female Humans Hypertension / complications, pathology Hypertriglyceridemia / genetics Insulin Resistance / genetics* Linear Models Male |
| Chemical | |
Reg. No./Substance:
|
0/Blood Glucose; 0/Cholesterol, HDL; 60-27-5/Creatinine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Remission of refractory minimal change nephrotic syndrome after basiliximab therapy.
Next Document: Therapeutic experience on multiple contractures in sclerodermoid chronic graft versus host disease.