Document Detail

Albumin--vitamin D-binding protein haplotypes in Asian-Pacific populations.
MedLine Citation:
PMID:  1972697     Owner:  NLM     Status:  MEDLINE    
We have determined the various haplotypic combinations between alleles as well as restriction fragment length polymorphisms of two linked genetic markers, albumin and vitamin D-binding protein or group-specific component, in a number of Asian-Pacific populations. Using the partial maximum likelihood method, we constructed a phylogenetic network from the haplotype frequencies to assess relationships among the populations sampled. No systematic linkage disequilibrium was detected between most of the combinations, suggesting a lack of operation of any selection pressure at the two loci. The phylogenetic analysis confirmed the known interrelationships among various populations in the Asian-Pacific region. The Australian aborigines clustered closely with the non-Austronesian-speaking highlanders from Papua New Guinea, as expected. Similarly, the Austronesian-speaking Polynesians, Micronesians, and the Southeast Asians branched off together as a separate group. The position of the Austronesian-speaking Tolais from New Britain with respect to other populations from the Southwest Pacific was anomalous. The Tolais revealed a strong affinity with the Australian aborigines, which is inexplicable. The populations from China formed a tight cluster with other populations from the Asian-Pacific region. Genetic interrelationships of these populations with the white Australians were remote, which is in accordance with the known affinities of various human racial groups.
L Z Chen; S Easteal; P G Board; K M Summers; K K Bhatia; R L Kirk
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human genetics     Volume:  85     ISSN:  0340-6717     ISO Abbreviation:  Hum. Genet.     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-08-01     Completed Date:  1990-08-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7613873     Medline TA:  Hum Genet     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  89-97     Citation Subset:  IM    
John Curtin School of Medical Research, Australian National University, Canberra.
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MeSH Terms
DNA / genetics
Gene Frequency / genetics
Haplotypes / genetics*
Linkage Disequilibrium
Pacific Islands
Polymorphism, Restriction Fragment Length*
Serum Albumin / genetics*
Vitamin D-Binding Protein / genetics*
Reg. No./Substance:
0/Serum Albumin; 0/Vitamin D-Binding Protein; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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