| Albumin synthesis in premature infants: determination of turnover with [15N]glycine. | |
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MedLine Citation:
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PMID: 3797134 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Albumin turnover was studied in seven small premature infants who received a constant infusion of [15N]glycine for 60-72 h. Gas chromatography-mass spectrometry was used to measure the rate of appearance of [15N]glycine in albumin isolated from the blood. By comparing the linear increment of [15N]glycine in blood albumin with plateau labelling of urinary [15N]hippurate, which was assumed to reflect intrahepatic isotopic abundance in [15N]glycine, the fractional synthetic rate for albumin was found to be 0.09-0.177 day-1 (mean +/- SD = 0.122 +/- 0.041 day-1). The absolute synthesis rate for albumin was 0.3 +/- 0.099 g/dl plasma X day-1 and the total plasma synthetic rate was 117.6 +/- 37.0 mg/kg X day-1. The glycine flux was 326.0-927.7 mumol/kg X h-1 (mean +/- SD 516.7 +/- 218.4 mumol/kg hr-1). The percentage of the glycine flux incorporated into albumin in the total vasculature was 0.425 +/- 0.344. The fractional synthetic rate and the absolute synthetic rate for albumin in these small premature infants are much higher than values obtained in healthy young adults studied with a similar methodology. The relatively low serum albumin concentrations typical of premature infants appear to be referable to more rapid turnover of a small plasma pool rather than a diminution in the rate of albumin synthesis. |
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Authors:
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M Yudkoff; I Nissim; W McNellis; R Polin |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Pediatric research Volume: 21 ISSN: 0031-3998 ISO Abbreviation: Pediatr. Res. Publication Date: 1987 Jan |
Date Detail:
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Created Date: 1987-02-19 Completed Date: 1987-02-19 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 49-53 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Gas Chromatography-Mass Spectrometry Gestational Age Glycine / blood* Hippurates / urine Humans Infant, Newborn Infant, Premature* Mathematics Serum Albumin / biosynthesis* Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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HD 08536/HD/NICHD NIH HHS; NS17752/NS/NINDS NIH HHS; RR00240/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hippurates; 0/Serum Albumin; 495-69-2/hippuric acid; 56-40-6/Glycine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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