Document Detail


Albumin mRNA in peripheral white blood cells of cirrhotic patients with a superimposed alcoholic hepatitis is associated to fatal outcome.
MedLine Citation:
PMID:  12393028     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The aim of this study was to analyze the relationship of plasma colloid osmotic pressure (COP), relative viscosity (eta) and overall outcome on the expression of albumin (ALB) mRNA in peripheral white blood cells (PWBC) of cirrhotic patients with superimposed alcoholic hepatitis (LC+AH). ALB messanger was detected in PWBC by RT-nPCR in control individuals (C), patients with liver cirrhosis (LC) and LC+AH. A higher number of LC+AH patients were positive to ALB mRNA (67%), compared to C (30%) and LC (28%). COP was decreased in LC and LC+AH groups compared to C group. No statistically significant changes were detected in eta in the different populations studied. Most of the LC+AH patients positive to peripheral ALB expression (87%) had a fatal outcome, compared to survivors (25%). Such difference was not observed with the conventional liver function tests or Maddrey's discriminant function.
Authors:
Blanca Estela Bastidas-Ramirez; Patricia Nuño-Gonzalez; Cecilia Vivas-Arceo; Laura V. Sánchez-Orozco; Arturo Panduro
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Hepatology research : the official journal of the Japan Society of Hepatology     Volume:  24     ISSN:  -     ISO Abbreviation:  Hepatol. Res.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-Oct-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9711801     Medline TA:  Hepatol Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  265     Citation Subset:  -    
Affiliation:
Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara Fray Antonio Alcalde, P.O. Box 2-500, 44280, Jal., Guadalajara, Mexico
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