Document Detail


Albumin dialysis MARS: knowledge from 10 years of clinical investigation.
MedLine Citation:
PMID:  19730006     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A decade ago, albumin dialysis was introduced as a new extracorporeal detoxification method for patients with liver failure. Today, the molecular adsorbent recirculating system is the most frequently used type of albumin dialysis and most studied liver-support technique. Numerous preclinical and clinical studies demonstrated the importance of albumin as a scavenger for molecules with pathophysiological relevance in liver failure. Albumin dialysis enables the selective regeneration of albumin. The resulting increase of albumin binding capacity is paralleled by improvement of central and local hemodynamics and liver, brain, and kidney functions. The treatment can contribute to liver regeneration and prolongation of patient survival in the context of acute liver failure, decompensated chronic liver disease, and bridging of patients to liver transplantation. Proper patient selection is critical for clinical success. Aggressive treatment of infections and sepsis seems to be a decisive prerequisite for its safe and efficient use. Cautious anticoagulation with heparin is the common standard. Citrate use is recommended for patients prone to bleeding. Taken together, albumin dialysis represents a valuable therapeutic tool for the treatment of various types of liver failure. Ongoing and future studies will help define the optimal patient selection and technical process parameters such as session length and frequency of treatment.
Authors:
Steffen R Mitzner; Jan Stange; Sebastian Klammt; Sebastian Koball; Heiko Hickstein; Emil C Reisinger
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  ASAIO journal (American Society for Artificial Internal Organs : 1992)     Volume:  55     ISSN:  1538-943X     ISO Abbreviation:  ASAIO J.     Publication Date:    2009 Sep-Oct
Date Detail:
Created Date:  2009-09-04     Completed Date:  2009-11-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204109     Medline TA:  ASAIO J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  498-502     Citation Subset:  IM    
Affiliation:
Division of Nephrology, Department of Medicine, University of Rostock, Rostock, Germany. steffen.mitzner@med.uni-rostock.de
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MeSH Terms
Descriptor/Qualifier:
Albumins / therapeutic use*
Animals
Clinical Trials as Topic
Dialysis / methods*
Humans
Liver Failure / therapy*
Membranes, Artificial
Chemical
Reg. No./Substance:
0/Albumins; 0/Membranes, Artificial

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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