| Albendazole therapy for coagulation abnormality in children with eosinophilia. | |
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MedLine Citation:
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PMID: 22568798 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Hemorrhage may be associated with eosinophilia. Here, 2 pediatric cases of coagulation abnormality were reported. The 2 children presented ecchymoses and petechiae in the skin. Laboratory investigations revealed hypereosinophilia in the peripheral blood. Moreover, the activity of coagulation factor IX significantly decreased. The serum immunoglobulin G (IgG) antibody to cysticercus was positive in patient 1, and IgG antibodies to cysticercus and plerocercoid were positive in patient 2. These 2 patients received 2 courses of albendazole therapy, at 15 mg/kg/day in divided doses for 10 days for each course. They responded well to the therapy. This report indicates that patients with hypereosinophilia and bleeding abnormalities should undergo evaluation of coagulation pathways, including measurements of coagulation factors. |
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Authors:
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Lu-Hong Xu; Jian-Pei Fang; Li-Na Zhang; Wen-Jun Weng; Ke Huang; Hai-Xia Guo |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pediatric hematology and oncology Volume: 29 ISSN: 1521-0669 ISO Abbreviation: Pediatr Hematol Oncol Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-05-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8700164 Medline TA: Pediatr Hematol Oncol Country: England |
Other Details:
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Languages: eng Pagination: 354-7 Citation Subset: IM |
Affiliation:
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1Department of Pediatrics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China ; and Key Laboratory of Malignant Tumor Gene Regulation and Target Therapy of Guangdong Higher Education Institutes, Sun Yat-sen University, Guangzhou, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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