Document Detail


Albendazole kinetics in patients with echinococcosis: delayed absorption and impaired elimination in cholestasis.
MedLine Citation:
PMID:  2373135     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pharmacokinetics of albendazole and its main metabolite, albendazole sulphoxide, have been examined after giving a single oral dose of 200 mg albendazole to 19 patients with either Echinococcus multilocularis or E. granulosus, 5 of whom had significant extrahepatic obstruction due to the underlying disease. The AUC of albendazole sulphoxide was increased in the latter patients (mean 122 mumols.h.l-1 compared to 17 mumols.h.l-1 in the non-obstructed group). Obstructed patients had delayed absorption, ka averaging 0.39 compared to 1.41 h-1 in non-obstructed patients. The corresponding elimination rate constant, ke was also prolonged, averaging 0.041 and 0.13 h-1 in the two groups, respectively. Four patients were restudied after complete or partial resolution of the cholestasis. The pharmacokinetic parameters in them had returned towards values comparable to those in the non-obstructed patients.
Authors:
J Cotting; T Zeugin; U Steiger; J Reichen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  38     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1990  
Date Detail:
Created Date:  1990-08-29     Completed Date:  1990-08-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  605-8     Citation Subset:  IM    
Affiliation:
Department of Clinical Pharmacology, University of Berne, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Albendazole / analogs & derivatives,  metabolism,  pharmacokinetics*
Cholestasis / metabolism*
Echinococcosis / metabolism*
Female
Half-Life
Humans
Intestinal Absorption
Male
Middle Aged
Chemical
Reg. No./Substance:
54029-12-8/albendazole sulfoxide; 54965-21-8/Albendazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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