Document Detail


Alaskan malamute chondrodysplasia--VIII. Incorporation of [14C]glucosamine and [3H]serine in hepatic metal-binding proteins of Canis familaris.
MedLine Citation:
PMID:  122576     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. Hepatic proteins isolated from control kennel dogs bound small quantities of zinc and iron and the peptide fraction contained neither metal. 2. Zince loading of kennel dogs stimulated an hepatic uptake of five times more zinc and three times more iron than an equivalent copper load. The increase in metal concentration was noted in the 10,000 dalton protein. 3. Both the 12,000 and 10,000 dalton proteins isolated from kennel dogs contained more binding sites specific for zinc than for either copper or iron. All three proteins isolated from Alaskan Malamutes showed a smaller affinity for zinc than copper or iron. 4. Both copper and zinc loading stimulated an uptake of [14C]glucosamine and [3H]serine from the peptide fraction of control kennel dogs into the 10,000 dalton protein.
Authors:
P A McBride-Warren; J S McCutcheon; R G Brown
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Comparative biochemistry and physiology. B, Comparative biochemistry     Volume:  63     ISSN:  0305-0491     ISO Abbreviation:  Comp. Biochem. Physiol., B     Publication Date:  1979  
Date Detail:
Created Date:  1989-07-21     Completed Date:  1989-07-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2984730R     Medline TA:  Comp Biochem Physiol B     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  569-76     Citation Subset:  IM    
Affiliation:
Department of Animal and Poultry Science, University of Guelph, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Carbon Radioisotopes
Dog Diseases / metabolism*
Dogs
Glucosamine / metabolism
Liver / metabolism*
Metalloproteins / biosynthesis*
Osteochondrodysplasias / metabolism,  veterinary*
Reference Values
Serine / metabolism
Species Specificity
Tritium
Grant Support
ID/Acronym/Agency:
AM 18758/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
0/Carbon Radioisotopes; 0/Metalloproteins; 10028-17-8/Tritium; 3416-24-8/Glucosamine; 56-45-1/Serine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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