Document Detail


Alarm pheromone increases defensive and risk assessment behaviors in male rats.
MedLine Citation:
PMID:  16337975     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Previously, we reported that alarm pheromone released from the perianal region of male rats aggravated stress-induced hyperthermia and increased Fos expression in the vomeronasal pathway and stress-related nuclei in pheromone-recipient rats. However, the alarm property of this pheromone in terms of behavior modification is still unclear. We recently found that this alarm pheromone could be trapped in water. Based on this finding, we developed an experimental paradigm to assess the effect of alarm pheromone on recipient behavior. Male Wistar rats were acclimatized for 5 min to an open field, where two pieces of filter paper soaked with 750 microl of either pheromone-containing water or vehicle water were attached to the wall. Then, a small "hiding box" was placed in one corner of the field and the behavioral responses of the subject rat were recorded for 10 subsequent minutes. Exposure to alarm pheromone significantly increased defensive and risk assessment behaviors and decreased exploratory and grooming behaviors compared to the vehicle control group, indicating the alarm property of the pheromone. In addition, the comparison with previous results suggests that the alarm pheromone released from the perianal region of the male rat increases anxiety in recipients, rather than evoking a stereotyped autonomic response.
Authors:
Yasushi Kiyokawa; Michito Shimozuru; Takefumi Kikusui; Yukari Takeuchi; Yuji Mori
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-12-09
Journal Detail:
Title:  Physiology & behavior     Volume:  87     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-02-06     Completed Date:  2006-04-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  383-7     Citation Subset:  IM    
Affiliation:
Laboratory of Veterinary Ethology, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan. kiyokawa-ns@umin.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Aggression / drug effects*
Animals
Anxiety / chemically induced,  psychology
Data Interpretation, Statistical
Exploratory Behavior / drug effects
Grooming / drug effects
Immunoenzyme Techniques
Male
Pheromones / pharmacology*
Rats
Rats, Wistar
Risk-Taking*
Chemical
Reg. No./Substance:
0/Pheromones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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