Document Detail

Alarin stimulates food intake in male rats and LH secretion in castrated male rats.
MedLine Citation:
PMID:  20434770     Owner:  NLM     Status:  MEDLINE    
Alarin is a newly identified member of the galanin family of neuropeptides that includes galanin-like peptide (GALP) and galanin. Alarin was discovered as an alternate transcript of the GALP gene in neuroblastoma cells, and subsequently alarin mRNA was detected in the brain of rodents. GALP and galanin are important central regulators of both feeding and reproductive behavior. We hypothesized, that, as a member of the galanin family of peptides, alarin would also have central effects on feeding and reproduction. To test this hypothesis, we treated male rats with alarin intracerebroventricularly (i.c.v.) and measured its effects on food intake and energy homeostasis as well as sexual behavior and luteinizing hormone (LH) secretion. We observed that i.c.v. injection of 1.0 nmol alarin significantly increased food intake (p<0.01) and body weight (p<0.05). Alarin did not affect sexual behavior in male rats; however, alarin did significantly (p<0.01) increase LH levels in castrated, but not intact, male rats. Alarin immunoreactive cell bodies were detected within the locus coeruleus and locus subcoeruleus of the midbrain, which is a brainstem nucleus involved in coordinating many physiological activities, including food intake and reproduction. Lastly, alarin stimulated Fos induction in hypothalamic nuclei, such as the paraventricular nucleus and the nucleus of the tractus solitarious. Our studies demonstrate that alarin, like other members of the galanin family, is a neuromediator of food intake and body weight.
Nicole Van Der Kolk; Farrah N Madison; Margaret Mohr; Nicole Eberhard; Barbara Kofler; Gregory S Fraley
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Neuropeptides     Volume:  44     ISSN:  1532-2785     ISO Abbreviation:  Neuropeptides     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-06-01     Completed Date:  2010-09-01     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  8103156     Medline TA:  Neuropeptides     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  333-40     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
Department of Biology, Hope College, Holland, MI 49423, USA.
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MeSH Terms
Body Weight / drug effects
Brain Chemistry / drug effects
Eating / drug effects*
Energy Metabolism / physiology
Galanin / pharmacology
Galanin-Like Peptide / metabolism,  pharmacology*
Injections, Intraventricular
Luteinizing Hormone / metabolism*
Oxygen Consumption / drug effects
Proto-Oncogene Proteins c-fos / biosynthesis
RNA, Messenger / biosynthesis,  genetics
Rats, Long-Evans
Reproduction / drug effects
Rhombencephalon / anatomy & histology,  drug effects,  physiology
Sexual Behavior, Animal / drug effects
Grant Support
K01 DK066238-01A1/DK/NIDDK NIH HHS; //Howard Hughes Medical Institute
Reg. No./Substance:
0/Galanin-Like Peptide; 0/Proto-Oncogene Proteins c-fos; 0/RNA, Messenger; 88813-36-9/Galanin; 9002-67-9/Luteinizing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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