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Is Alanine Aminotransferase Associated with Osteopenia in Middle-Aged and Elderly Chinese?
MedLine Citation:
PMID:  24518175     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective: To investigate the association between alanine aminotransferase levels and risk of osteopenia in middle-aged and elderly Chinese with ALT within normal range.Methods: This was a cross-sectional study. A total of 4,890 men and women (pre- and post menopause) aged 40 years or older were randomly recruited from Fujian, China. Each participant was required to complete a questionnaire, then undergo anthropometric, biochemical and BMD measurements.Results: The odds ratios of osteopenia decreased significantly with increasing alanine aminotransferase at baseline. The three groups (men, pre- and post-menopausal women) were divided by the quartiles of ALT, respectively. In multiple logistic regression models using the 1st quartile as the reference, after adjusting for corresponding confounding factors, the odds ratios and 95% confidence interval of osteopenia across the other quartiles of alanine aminotransferase were 0.576 (0.390-0.851), 0.654(0.460-0.930) and 0.629 (0.427-0.926) for premenopausal women, 0.949 (0.699-1.289), 0.733 (0.540-0.995) and 0.692 (0.508-0.943) for postmenopausal women (not significant for quartile2). However, no significant results were found in men. Multiple linear regression model showed that serum alanine aminotransferase concentrations were positively associated with HOMA-IR.Conclusions: The prevalence of osteopenia was inversely associated with the levels of alanine aminotransferase when alanine aminotransferase was within a normal range in middle-aged and elderly Chinese women.
Authors:
Gang Chen; Ling Chen; Baoying Huang; Changsheng Qiu; Jieli Lu; Yufang Bi; Guang Ning; Jixing Liang; Junping Wen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-2-11
Journal Detail:
Title:  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists     Volume:  -     ISSN:  1934-2403     ISO Abbreviation:  Endocr Pract     Publication Date:  2014 Feb 
Date Detail:
Created Date:  2014-2-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9607439     Medline TA:  Endocr Pract     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-34     Citation Subset:  -    
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