| Ala92 type 2 deiodinase allele increases risk for the development of hypertension. | |
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MedLine Citation:
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PMID: 17224473 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Accumulating evidence suggests that genes of the hypothalamic-pituitary-thyroid pathway influence susceptibility to hypertension. Type 2 iodothyronine deiodinase is responsible for the conversion of thyroxine to tri-iodothyronine for use in peripheral tissues. The present study evaluated whether a type 2 iodothyronine deiodinase nonsynonymous polymorphism, threonine 92 to alanine (Thr92Ala), is a determinant of hypertension susceptibility. A total of 372 euthyroid subjects were genotyped for Thr92Ala polymorphism using the Sequenom MassARRAY platform. Associations with hypertension and hypertension-related intermediate phenotypes were performed with generalized estimating equations. Type 2 iodothyronine deiodinase Thr92Ala allele frequencies differed significantly between hypertensive and normotensive subjects, with an excess of Ala92 carriers in hypertensive compared with normotensive subjects (64.8% versus 47.1%; P=0.011). Adjusted for age, gender and race, the estimated odds ratio for hypertension in Ala92 allele carriers compared with Thr92 homozygotes was 2.11 (95% CI: 1.15 to 3.89). Among euthyroid adults, the common Ala92 allele of the type 2 iodothyronine deiodinase increases risk for the development of hypertension. These data support an important role for genetic variation in the hypothalamic-pituitary-thyroid pathway in influencing susceptibility to hypertension. |
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Authors:
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Olga Gumieniak; Todd S Perlstein; Jonathan S Williams; Paul N Hopkins; Nancy J Brown; Benjamin A Raby; Gordon H Williams |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2007-01-15 |
Journal Detail:
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Title: Hypertension Volume: 49 ISSN: 1524-4563 ISO Abbreviation: Hypertension Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-02-16 Completed Date: 2007-03-06 Revised Date: 2008-04-16 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: United States |
Other Details:
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Languages: eng Pagination: 461-6 Citation Subset: IM |
Affiliation:
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Endocrinology, Diabetes, and Hypertension Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass 02115, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alleles Female Genetic Predisposition to Disease Humans Hypertension / genetics* Iodide Peroxidase / genetics* Male Middle Aged Polymorphism, Genetic |
| Grant Support | |
ID/Acronym/Agency:
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DK63214/DK/NIDDK NIH HHS; HL47651/HL/NHLBI NIH HHS; HL55000/HL/NHLBI NIH HHS; HL59424/HL/NHLBI NIH HHS; M01 RR 00064/RR/NCRR NIH HHS; M01 RR 00095/RR/NCRR NIH HHS; M01 RR 02635/RR/NCRR NIH HHS; T32 HL007609/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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EC 1.11.1.-/iodothyronine deiodinase type II; EC 1.11.1.8/Iodide Peroxidase |
| Comments/Corrections | |
Comment In:
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Hypertension. 2007 Jun;49(6):e47; author reply e48
[PMID:
17389255
]
Hypertension. 2008 Apr;51(4):e22-3 [PMID: 18285610 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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