Document Detail


Ala92 type 2 deiodinase allele increases risk for the development of hypertension.
MedLine Citation:
PMID:  17224473     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Accumulating evidence suggests that genes of the hypothalamic-pituitary-thyroid pathway influence susceptibility to hypertension. Type 2 iodothyronine deiodinase is responsible for the conversion of thyroxine to tri-iodothyronine for use in peripheral tissues. The present study evaluated whether a type 2 iodothyronine deiodinase nonsynonymous polymorphism, threonine 92 to alanine (Thr92Ala), is a determinant of hypertension susceptibility. A total of 372 euthyroid subjects were genotyped for Thr92Ala polymorphism using the Sequenom MassARRAY platform. Associations with hypertension and hypertension-related intermediate phenotypes were performed with generalized estimating equations. Type 2 iodothyronine deiodinase Thr92Ala allele frequencies differed significantly between hypertensive and normotensive subjects, with an excess of Ala92 carriers in hypertensive compared with normotensive subjects (64.8% versus 47.1%; P=0.011). Adjusted for age, gender and race, the estimated odds ratio for hypertension in Ala92 allele carriers compared with Thr92 homozygotes was 2.11 (95% CI: 1.15 to 3.89). Among euthyroid adults, the common Ala92 allele of the type 2 iodothyronine deiodinase increases risk for the development of hypertension. These data support an important role for genetic variation in the hypothalamic-pituitary-thyroid pathway in influencing susceptibility to hypertension.
Authors:
Olga Gumieniak; Todd S Perlstein; Jonathan S Williams; Paul N Hopkins; Nancy J Brown; Benjamin A Raby; Gordon H Williams
Related Documents :
18082523 - Relation of haptoglobin phenotype to early vascular changes in patients with diabetes m...
14975123 - Multivariate variance-components analysis of longitudinal blood pressure measurements f...
16181713 - Center of pressure excursion capability in performance of seated lateral-reaching tasks.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2007-01-15
Journal Detail:
Title:  Hypertension     Volume:  49     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-02-16     Completed Date:  2007-03-06     Revised Date:  2008-04-16    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  461-6     Citation Subset:  IM    
Affiliation:
Endocrinology, Diabetes, and Hypertension Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass 02115, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Alleles
Female
Genetic Predisposition to Disease
Humans
Hypertension / genetics*
Iodide Peroxidase / genetics*
Male
Middle Aged
Polymorphism, Genetic
Grant Support
ID/Acronym/Agency:
DK63214/DK/NIDDK NIH HHS; HL47651/HL/NHLBI NIH HHS; HL55000/HL/NHLBI NIH HHS; HL59424/HL/NHLBI NIH HHS; M01 RR 00064/RR/NCRR NIH HHS; M01 RR 00095/RR/NCRR NIH HHS; M01 RR 02635/RR/NCRR NIH HHS; T32 HL007609/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
EC 1.11.1.-/iodothyronine deiodinase type II; EC 1.11.1.8/Iodide Peroxidase
Comments/Corrections
Comment In:
Hypertension. 2007 Jun;49(6):e47; author reply e48   [PMID:  17389255 ]
Hypertension. 2008 Apr;51(4):e22-3   [PMID:  18285610 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Left ventricular mass, blood pressure, and lowered cognitive performance in the Framingham offspring...
Next Document:  Endocrine role of the renin-angiotensin system in human adipose tissue and muscle: effect of beta-ad...