| Ala54Thr polymorphism of fatty acid-binding protein 2 gene and fasting blood lipids: a meta-analysis. | |
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MedLine Citation:
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PMID: 20047744 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The results from the published studies on the association of fatty acid-binding protein 2 (FABP2) Ala54Thr polymorphism with dyslipidemia are conflicting and inconclusive. In this meta-analysis encompassing all the relevant studies, we aimed to investigate the association of the FABP2 Ala54Thr polymorphism with fasting blood lipids. METHODS: We limited our analysis to the following four blood lipid parameters: total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C). Subjects were confined to adults who were at least 18 years old. A dominant model was used for this meta-analysis. RESULTS: 30 studies with 14,401 subjects were included in this meta-analysis. The results showed that the carriers of Thr54 allele have higher blood TC and LDL-C than the non-carriers: standardized mean difference (SMD)=0.07, 95% CI (confidence interval, 0.02, 0.11), P=0.005, Pheterogeneity=0.12, and SMD=0.09, 95% CI (0.03, 0.15), P=0.002, Pheterogeneity=0.0006, respectively. Significant association between the Ala54Thr polymorphism and lower blood HDL-C was also detected under the dominant models: SMD=-0.05, 95% CI (-0.09, -0.00), P=0.04, Pheterogeneity=0.10. CONCLUSIONS: Our meta-analysis supports the strong association between the Thr54 allele of the FABP2 Ala54Thr polymorphism with higher levels of TC and LDL-C, and lower levels of HDL-C. |
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Authors:
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Tongfeng Zhao; Marius Nzekebaloudou; Jing lv |
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Publication Detail:
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Type: Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't Date: 2009-12-04 |
Journal Detail:
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Title: Atherosclerosis Volume: 210 ISSN: 1879-1484 ISO Abbreviation: Atherosclerosis Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-31 Completed Date: 2010-12-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
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Languages: eng Pagination: 461-7 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Geriatrics, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310000, China. zhaotongfeng@yahoo.com.cn |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Alanine / genetics* Alleles Cholesterol, HDL / metabolism Cholesterol, LDL / metabolism Dyslipidemias / genetics* Fatty Acid-Binding Proteins / metabolism* Female Homozygote Humans Male Middle Aged Polymorphism, Genetic* Threonine / genetics* |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/FABP2 protein, human; 0/Fatty Acid-Binding Proteins; 56-41-7/Alanine; 72-19-5/Threonine |
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