| AlMe(3)-Promoted Formation of Amides from Acids and Amines. | |
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MedLine Citation:
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PMID: 22148911 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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In the presence of AlMe(3), amines can be directly coupled with acids through dimethylaluminum amide intermediates to form the corresponding amides. A wide range of amines and acids including less nucleophilic amines, bulky amines, unprotected secondary amino acids, and acids with poor solubility were coupled smoothly to give the desired products in 55-98% yields. |
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Authors:
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Jianqing Li; Krishnananthan Subramaniam; Daniel Smith; Jennifer X Qiao; Jie Jack Li; Jingfang Qian-Cutrone; John F Kadow; Gregory D Vite; Bang-Chi Chen |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-7 |
Journal Detail:
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Title: Organic letters Volume: - ISSN: 1523-7052 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100890393 Medline TA: Org Lett Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Bristol-Myers Squibb Company, Research and Development, P.O. Box 4000, Princeton, New Jersey 08543-4000, United States, 311 Pennington-Rocky Hill Road, Pennington, New Jersey 08534, United States, and 5 Research Parkway, Wallingford, Connecticut 06492, United States. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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