Document Detail


Akt/protein kinase B in skeletal muscle physiology and pathology.
MedLine Citation:
PMID:  20672327     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Akt/protein kinase B is critical regulator of cellular homeostasis with diminished Akt activity being associated with dysregulation of cellular metabolism and cell death while Akt over-activation has been linked to inappropriate cell growth and proliferation. Although the regulation of Akt function has been well characterized in vitro, much less is known regarding the function of Akt in vivo. Here we examine how skeletal muscle Akt expression and enzymatic activity are controlled, the role of Akt in the regulation of skeletal muscle contraction, stress response glucose utilization, and protein metabolism, and the potential participation of this important molecule in skeletal muscle atrophy, aging, and cancer.
Authors:
Miaozong Wu; Marco Falasca; Eric R Blough
Related Documents :
16424087 - Ankyrin repeat and socs box protein 15 regulates protein synthesis in skeletal muscle.
6715547 - Inhibitors of prostaglandin synthesis or cathepsin b prevent muscle wasting due to seps...
24259937 - Maximal torque and muscle strength is affected by seat distance from the steering wheel...
20500987 - Contribution of hexose-6-phosphate dehydrogenase to nadph content and redox environment...
1857027 - Differential intracardiac sympathetic and parasympathetic innervation to the sa and av ...
13658967 - Prolongation of response of node of ranvier by metal ions.
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of cellular physiology     Volume:  226     ISSN:  1097-4652     ISO Abbreviation:  J. Cell. Physiol.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-10-27     Completed Date:  2010-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0050222     Medline TA:  J Cell Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  29-36     Citation Subset:  IM    
Affiliation:
Center for Diagnostic Nanosystems, Marshall University, Huntington, West Virginia 25755-1090, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Gene Expression Regulation / physiology
Humans
Muscle, Skeletal / physiology*
Muscular Diseases / metabolism*,  pathology
Proto-Oncogene Proteins c-akt / genetics,  metabolism*
Chemical
Reg. No./Substance:
EC 2.7.11.1/Proto-Oncogene Proteins c-akt

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Brain natriuretic peptide modulates the delayed rectifier outward K(+) current and promotes the prol...
Next Document:  Expression, localization, and regulation of the neuregulin receptor ErbB3 in mouse heart.