Document Detail

Akt/protein kinase B in skeletal muscle physiology and pathology.
MedLine Citation:
PMID:  20672327     Owner:  NLM     Status:  MEDLINE    
The Akt/protein kinase B is critical regulator of cellular homeostasis with diminished Akt activity being associated with dysregulation of cellular metabolism and cell death while Akt over-activation has been linked to inappropriate cell growth and proliferation. Although the regulation of Akt function has been well characterized in vitro, much less is known regarding the function of Akt in vivo. Here we examine how skeletal muscle Akt expression and enzymatic activity are controlled, the role of Akt in the regulation of skeletal muscle contraction, stress response glucose utilization, and protein metabolism, and the potential participation of this important molecule in skeletal muscle atrophy, aging, and cancer.
Miaozong Wu; Marco Falasca; Eric R Blough
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of cellular physiology     Volume:  226     ISSN:  1097-4652     ISO Abbreviation:  J. Cell. Physiol.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-10-27     Completed Date:  2010-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0050222     Medline TA:  J Cell Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  29-36     Citation Subset:  IM    
Center for Diagnostic Nanosystems, Marshall University, Huntington, West Virginia 25755-1090, USA.
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MeSH Terms
Gene Expression Regulation / physiology
Muscle, Skeletal / physiology*
Muscular Diseases / metabolism*,  pathology
Proto-Oncogene Proteins c-akt / genetics,  metabolism*
Reg. No./Substance:
EC Proteins c-akt

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