Document Detail


Akinetic mutism with bithalamic infarction. Neurophysiological correlates.
MedLine Citation:
PMID:  8836973     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A 42-year-old man presented with akinetic mutism, caused by bilateral thalamic infarction, resulting in a temporary amnesic syndrome and, finally, selective downgaze palsy. Electroencephalographic recording in the initial phase showed generalized spike- and-wave discharges, similar to those found in animal studies after lesion or stimulation of specific thalamic nuclei. Analysis of magnetic resonance images (MRI) of the head showed that the centre of ischemic necrosis particularly involved the intralaminar thalamic nuclei and a small part of the rostral mesencephalon. The findings support the previously suggested involvement of cortico-thalamo-mesencephalic circuitry in the initiation of motor responses, and the association of the non-specific thalamic nuclei with the appearance of generalized epileptiform phenomena in cases of reduced vigilance.
Authors:
P H van Domburg; H J ten Donkelaar; S L Notermans
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  139     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1996-12-23     Completed Date:  1996-12-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  58-65     Citation Subset:  IM    
Affiliation:
Department of Neurology, University Hospital Nijmegen, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Adult
Amnesia
Cerebral Infarction / pathology,  physiopathology*,  radiography
Electroencephalography
Humans
Magnetic Resonance Imaging
Male
Mutism / physiopathology*,  radiography
Necrosis
Paralysis
Thalamus / pathology,  radiography
Tomography, X-Ray Computed

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