| Akinetic Mutism Caused by HIV-associated Progressive Multifocal Leukoencephalopathy was Successfully Treated with Mefloquine: A Serial Multimodal MRI Study. | |
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MedLine Citation:
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PMID: 22246492 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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We report a case of a patient with highly active anti-retroviral therapy-resistant human immunodeficiency virus (HIV)-associated progressive multifocal leukoencephalopathy (PML). The patient showed an improvement in imaging findings and clinical symptoms after mefloquine was introduced as an additional treatment. Serial assessment of white matter lesions was conducted by proton magnetic resonance spectroscopy ((1)H-MRS) and diffusion-weighted imaging (DWI). As the clinical symptoms improved, the N-acetylaspartate/creatine ratio increased, the choline/creatine ratio decreased, and the elevated ADC value decreased. These concomitant changes suggested that (1)H-MRS and DWI were useful for the assessment of the therapeutic effect on PML. |
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Authors:
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Kasane Naito; Hiroki Ueno; Mayu Sekine; Munekazu Kanemitsu; Tomohiko Ohshita; Takeshi Nakamura; Takemori Yamawaki; Masayasu Matsumoto |
Publication Detail:
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Type: Journal Article Date: 2012-01-15 |
Journal Detail:
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Title: Internal medicine (Tokyo, Japan) Volume: 51 ISSN: 1349-7235 ISO Abbreviation: Intern. Med. Publication Date: 2012 |
Date Detail:
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Created Date: 2012-01-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9204241 Medline TA: Intern Med Country: Japan |
Other Details:
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Languages: eng Pagination: 205-9 Citation Subset: IM |
Affiliation:
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Department of Clinical Neuroscience and Therapeutics, Hiroshima University, Graduate School of Biomedical Sciences, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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