| Ajmaline Challenge in Young Individuals with Suspected Brugada Syndrome. | |
MedLine Citation:
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PMID: 21303388 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: The clinical characteristics and the results of ajmaline challenge in young individuals with suspected Brugada syndrome (BS) have not been systematically investigated. Methods: Among a larger series of patients included in the BS database of our Department, 179 patients undergoing ajmaline challenge were included in the study and categorized in two groups according to age: group 1 (<18 years old) and group 2 (≥18 years old). Clinical features and results of the ajmaline challenge of each group were compared. Results: Young individuals were more often asymptomatic compared to adult patients (P = 0.002). They showed a higher number of normal ECGs (P = 0.023), a lower percentage of Brugada type II electrocardiographic pattern compared to the adult population (P = 0.011), and a comparable amount of spontaneous Brugada type III electrocardiographic pattern (P = 0.695). Ajmaline provoked a higher degree of intraventricular conduction delay (P = 0.002) and higher degree of prolongation of the ventricular repolarization phase (P = 0.013) in young individuals but its pro-arrhythmic risk was comparable in the two groups (P = 0.684). Furthermore, inducibility of ventricular arrhythmias in young patients with a positive ajmaline test was comparable to that of the adults with a positive ajmaline test (P = 0.694). Conclusions: The present study demonstrates the low-risk profile of the ajmaline test in young patients when performed by experienced physicians and nurses in an appropriate environment. (PACE 2011; 1-6). |
Authors:
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Antonio Sorgente; Andrea Sarkozy; Carlo DE Asmundis; Gian-Battista Chierchia; Lucio Capulzini; Gaetano Paparella; Stefan Henkens; Pedro Brugada |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-8 |
Journal Detail:
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Title: Pacing and clinical electrophysiology : PACE Volume: - ISSN: 1540-8159 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7803944 Medline TA: Pacing Clin Electrophysiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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©2011, The Authors. Journal compilation ©2011 Wiley Periodicals, Inc. |
Affiliation:
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Heart Rhythm Management Center, UZ Brussel-VUB, Brussels, Belgium Department of Cardiology, University of L'Aquila, L'Aquila, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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