Document Detail

Airways hyperresponsiveness to different inhaled combination therapies in adolescent asthmatics.
MedLine Citation:
PMID:  22519127     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Inhaled combined therapy improves the pulmonary function in asthmatic patients. The effect on the airway hyperresponsiveness (AHR) and the efficacy of different pharmacological schedules is not well clarified on adolescent asthmatics.
OBJECTIVE: Evaluate the responses to different combined inhaled therapies in adolescent asthmatics and study its impact on exercise induced AHR.
METHODS: Basal lung function tests (LFT) were performed in 30 adolescents (13 to 16 years old; 19 female) with allergic asthma. They were submitted to exercise challenge test (EC) followed by bronchodilator test (BD). During 4 weeks, 15 adolescents were submitted to inhaled fluticasone/salmeterol (group A) and other 15 to inhaled budesonide/formoterol (group B). After this period, they underwent another functional evaluation as previous.
RESULTS: Before treatment, pulmonary function was similar in both groups. After 4 weeks of treatment, these groups showed an improvement of the basal LFT (p = 0.001 for FEV1 in both), decrease on bronchoconstriction induced by exercise (NS for both) and less recovery on BD response (p = 0.001 and 0.002, for FEV1 respectively groups A and B). Group B showed a better performance, with higher improvement of basal FEF 25/75 (p = 0.001), reduced bronchoconstriction response to EC (p = 0.008 for FEV1) and fewer response to BD test (p < 0.0001 for FEV1 and 0.024 for FEF 25/75) No adverse events were observed.
CONCLUSION: After 4 weeks of inhaled combined therapy, these patients improved their pulmonary function and bronchomotricity. Those under budesonide/formoterol showed the highest improvement. These medications are a safe measure in controlling the asthma in these patients.
D Machado; C Pereira; B Tavares; G Loureiro; A Segorbe-Luís
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  European annals of allergy and clinical immunology     Volume:  44     ISSN:  1764-1489     ISO Abbreviation:  Eur Ann Allergy Clin Immunol     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-04-23     Completed Date:  2012-05-15     Revised Date:  2013-06-11    
Medline Journal Info:
Nlm Unique ID:  101466614     Medline TA:  Eur Ann Allergy Clin Immunol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  12-7     Citation Subset:  IM    
Coimbra University Hospitals, Immunoallergy Department, Coimbra, Portugal.
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MeSH Terms
Albuterol / analogs & derivatives*,  therapeutic use
Androstadienes / therapeutic use*
Asthma / drug therapy*
Asthma, Exercise-Induced / drug therapy
Bronchial Hyperreactivity / drug therapy*
Bronchodilator Agents / therapeutic use*
Budesonide / therapeutic use*
Drug Combinations
Ethanolamines / therapeutic use*
Respiratory Function Tests
Reg. No./Substance:
0/Androstadienes; 0/Bronchodilator Agents; 0/Drug Combinations; 0/Ethanolamines; 0/fluticasone, salmeterol drug combination; 18559-94-9/Albuterol; 51333-22-3/Budesonide; 5ZZ84GCW8B/formoterol

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