Document Detail


Airway transplantation.
MedLine Citation:
PMID:  24295665     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
No definitive solution has been discovered for replacing long segments or the entire trachea in humans. Most of this challenge stems from the specific function and mechanics that are almost impossible to replicate except in the setting of an allotransplantation, which requires lifelong immunosuppressive medication. Recently, tissue engineering provided significant evidence concerning the next promising therapeutic alternative for tracheal replacement. Underlying mechanism and pathways of cell-surface interactions, cell migration, and differentiation are essential to understand the complexity of tracheal tissue regeneration. Tracheal replacement remains challenging but initial steps toward an ideal therapeutic concept have been made.
Authors:
Philipp Jungebluth; Paolo Macchiarini
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Thoracic surgery clinics     Volume:  24     ISSN:  1547-4127     ISO Abbreviation:  Thorac Surg Clin     Publication Date:  2014 Feb 
Date Detail:
Created Date:  2013-12-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101198195     Medline TA:  Thorac Surg Clin     Country:  United States    
Other Details:
Languages:  eng     Pagination:  97-106     Citation Subset:  IM    
Copyright Information:
Copyright © 2014 Elsevier Inc. All rights reserved.
Affiliation:
Division of Ear, Nose, and Throat (CLINTEC), Advanced Center for Translational Regenerative Medicine (ACTREM), Karolinska Institutet, Alfred Nobel Allé 8, Huddinge/Stockholm 14186, Sweden.
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