| Airway responsiveness to inhaled albuterol in patients with pulmonary hypertension. | |
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MedLine Citation:
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PMID: 9924639 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied patients with pulmonary hypertension who had evidence of bronchial responsiveness to inhaled albuterol. The records of all patients evaluated for lung transplantation were reviewed: the charts of patients with pulmonary hypertension, either primary (PPH, n = 46) or Eisenmenger's syndrome (n = 12), were abstracted. Measurements of lung function revealed equal numbers of patients with normal, restrictive, obstructive, and mixed abnormalities. None were more than moderate. Airway responsiveness was defined as an increase of forced expiratory volume in 1 second (FEV1) > 15% or forced expiratory flow between 25% and 75% of the vital capacity (FEF25-75) > 25%. Of the 24 PPH and nine Eisenmenger's patients, 14 and four, respectively, had reversible airflow obstruction. These patients were more likely to have a history of atopic disease and to have responded to calcium channels blockers during hemodynamic monitoring. They did not have more severe pulmonary hypertension, as measured by hemodynamic monitoring. Four patients had a history of asthma, which required hospitalization in three. Reversible airflow obstruction occurred in half of the patients with pulmonary hypertension and was clinically important in at least three. |
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Authors:
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A R O'Hagan; P C Stillwell; A Arroliga |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Clinical pediatrics Volume: 38 ISSN: 0009-9228 ISO Abbreviation: Clin Pediatr (Phila) Publication Date: 1999 Jan |
Date Detail:
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Created Date: 1999-03-18 Completed Date: 1999-03-18 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372606 Medline TA: Clin Pediatr (Phila) Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 27-33 Citation Subset: AIM; IM |
Affiliation:
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Cleveland Clinic Foundation, Ohio, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Airway Resistance / drug effects* Albuterol / diagnostic use*, pharmacology Bronchodilator Agents / diagnostic use Bronchography Child Eisenmenger Complex / diagnosis*, surgery Female Humans Hypertension, Pulmonary / diagnosis*, surgery Lung Transplantation* Male Middle Aged Respiratory Function Tests |
| Chemical | |
Reg. No./Substance:
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0/Bronchodilator Agents; 18559-94-9/Albuterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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