Document Detail

Airway responsiveness in low birthweight children and their mothers.
MedLine Citation:
PMID:  3415325     Owner:  NLM     Status:  MEDLINE    
In a prospective study on a cohort of 7 year old children of low birth weight (under 2000 g at birth), we observed an increased prevalence of airway responsiveness to histamine compared with a reference population of unselected, local schoolchildren. The airway responsiveness to histamine was significantly related to a history of asthma in first degree relatives (natural parents and siblings) in both groups of children, but not to that of the mothers. There was no increase in the prevalence of maternal asthma, a family history of asthma, or airway responsiveness in the mothers of low birthweight children. We were unable to find evidence to support the hypothesis that maternal smooth muscle irritability (uterine and airway) has a causative role in the premature labour in the mothers and in subsequent bronchial hyper-responsiveness in their prematurely born children.
K N Chan; C M Noble-Jamieson; A Elliman; E M Bryan; V R Aber; M Silverman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of disease in childhood     Volume:  63     ISSN:  1468-2044     ISO Abbreviation:  Arch. Dis. Child.     Publication Date:  1988 Aug 
Date Detail:
Created Date:  1988-10-07     Completed Date:  1988-10-07     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372434     Medline TA:  Arch Dis Child     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  905-10     Citation Subset:  AIM; IM    
Paediatric Department, Royal Postgraduate Medical School, Hammersmith Hospital, London.
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MeSH Terms
Asthma / genetics
Bronchi / drug effects*
Bronchial Provocation Tests
Histamine / pharmacology*
Infant, Low Birth Weight / physiology*
Infant, Newborn
Obstetric Labor, Premature / complications
Prospective Studies
Respiratory Hypersensitivity / complications,  etiology*,  genetics
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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