Document Detail


Airway responses to methacholine in asymptomatic nonatopic cigarette smokers.
MedLine Citation:
PMID:  3298197     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We prospectively performed methacholine bronchoprovocation challenges on 46 young smokers to examine the effects of cigarette smoking on airway responsiveness. The subjects, ages 18-35 yr, had no past or present history or physical examination findings of asthma or other lung diseases, rhinitis, allergic diseases, or respiratory infections; were skin test negative to 29 common aeroallergens; and had base-line pulmonary function values greater than 80% predicted. Sixteen of 46 (35%) subjects had a 20% or greater drop in forced expiratory volume in 1 s at a provocative methacholine concentration less than or equal to 25 mg/ml. The degree of methacholine responsiveness was not dependent upon base-line pulmonary function values or the amount of cigarettes consumed, and there was no association between the amount of cigarettes consumed and base-line pulmonary function values. These data suggest that many young asymptomatic nonatopic smokers have increased airway responsiveness to inhaled methacholine without clinically significant hyperreactive airway disease.
Authors:
T B Casale; B J Rhodes; A L Donnelly; J M Weiler
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  62     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1987 May 
Date Detail:
Created Date:  1987-08-04     Completed Date:  1987-08-04     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1888-92     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Airway Resistance / drug effects*
Bronchi / drug effects,  physiology
Bronchial Provocation Tests
Female
Forced Expiratory Volume
Humans
Male
Methacholine Chloride
Methacholine Compounds / pharmacology*
Smoking*
Vital Capacity
Chemical
Reg. No./Substance:
0/Methacholine Compounds; 62-51-1/Methacholine Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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