| Airway responses to methacholine and exercise at high altitude in healthy lowlanders. | |
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MedLine Citation:
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PMID: 19940099 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Peribronchial edema has been proposed as a mechanism enhancing airway responses to constrictor stimuli. Acute exposure to altitude in nonacclimatized lowlanders leads to subclinical interstitial pulmonary edema that lasts for several days after ascent, as suggested by changes in lung mechanics. We, therefore, investigated whether changes in lung mechanics consistent with fluid accumulation at high altitude within the lungs are associated with changes in airway responses to methacholine or exercise. Fourteen healthy subjects were studied at 4,559 and at 120 m above sea level. At high altitude, both static and dynamic lung compliances and respiratory reactance at 5 Hz significantly decreased, suggestive of interstitial pulmonary edema. Resting minute ventilation significantly increased by approximately 30%. Compared with sea level, inhalation of methacholine at high altitude caused a similar reduction of partial forced expiratory flow but less reduction of maximal forced expiratory flow, less increments of pulmonary resistance and respiratory resistance at 5 Hz, and similar effects of deep breath on pulmonary and respiratory resistance. During maximal incremental exercise at high altitude, partial forced expiratory flow gradually increased with the increase in minute ventilation similarly to sea level but both achieved higher values at peak exercise. In conclusion, airway responsiveness to methacholine at high altitude is well preserved despite the occurrence of interstitial pulmonary edema. We suggest that this may be the result of the increase in resting minute ventilation opposing the effects and/or the development of airway smooth muscle force, reduced gas density, and well preserved airway-to-parenchyma interdependence. |
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Authors:
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Riccardo Pellegrino; Pasquale Pompilio; Marco Quaranta; Andrea Aliverti; Bengt Kayser; Giuseppe Miserocchi; Valter Fasano; Annalisa Cogo; Manlio Milanese; Giuseppe Cornara; Vito Brusasco; Raffaele Dellacà |
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Publication Detail:
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Type: Journal Article Date: 2009-11-25 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 108 ISSN: 1522-1601 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-01 Completed Date: 2010-04-23 Revised Date: 2010-08-18 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 256-65 Citation Subset: IM |
Affiliation:
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Allergologia e Fisiopatologia Respiratoria, Azienda Ospedaliera S. Croce e Carle, Cuneo, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acclimatization Adult Airway Resistance / physiology Altitude* Blood Volume / physiology Bronchi / drug effects, physiology Exercise / physiology* Exercise Test Forced Expiratory Flow Rates / physiology Humans Lung / drug effects, physiology Lung Compliance / physiology Lung Volume Measurements Male Methacholine Chloride / pharmacology* Middle Aged Muscarinic Agonists / pharmacology* Respiratory Function Tests Respiratory Mechanics / drug effects Tidal Volume / physiology |
| Chemical | |
Reg. No./Substance:
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0/Muscarinic Agonists; 62-51-1/Methacholine Chloride |
| Comments/Corrections | |
Comment In:
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J Appl Physiol. 2010 Apr;108(4):765-6
[PMID:
20133442
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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