| Airway resistance in chronic heart failure measured by impulse oscillometry. | |
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MedLine Citation:
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PMID: 12397570 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Patients with chronic heart failure (CHF) complain of breathlessness and fatigue on exertion, have reduced peak oxygen consumption (pV(O(2))), and an increased ventilatory response to exercise (V(E)/V(CO(2)) slope). These limitations correlate with abnormalities of spirometry (forced expiratory volume in 1 second [FEV(1)] and forced ventilatory capacity [FVC]). Increased airway resistance by increasing the work of breathing might contribute to exercise intolerance in CHF. METHODS: Impulse oscillometry (IOS) measures airway resistance and lung compliance independently of respiratory muscle strength and patient compliance. Sound waves of varying frequencies are sent into the lungs and the amplitude and phase shift of the reflected waves give a measure of airway resistance (R) and reactance (X). Twenty-three CHF patients and 18 controls underwent peak exercise testing with metabolic gas analysis and had airway resistance assessment using the Jaeger (Würtzberg, Germany) IOS system. RESULTS: Patients had a lower pV(O(2)) (18.7 (4.0) v 39.2 (8.3) mL x kg x min; P < .0001), elevated V(E)/V(CO(2)) slope (41.6 (8.1) v 27.4 (2.9)), and lower FEV(1) (2.4 (0.4) v 3.2 (0.7) L/min; P = .0001) and FVC (3.3 (0.7) v 4.1 (1.1) L; P < .005) than controls. R and X correlated with spirometric abnormalities and were different between patients and controls (R at 5 Hz 0.44 (0.16) v 0.30 (0.15) kPa (L/s); P < .005 and X at 5 Hz -0.16 (0.08) v -0.09 (0.08) kPa (L/s); P < .05). R at 5 Hz correlated with pV(O(2)) (0.46; P = .0025) and V(E)/V(CO(2)) slope (0.43; P < .05). CONCLUSION: CHF patients have elevated airway resistance and reduced reactance measured with IOS compared with control subjects. |
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Authors:
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Klaus K A Witte; Alyn Morice; Andrew L Clark; John G F Cleland |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of cardiac failure Volume: 8 ISSN: 1071-9164 ISO Abbreviation: J. Card. Fail. Publication Date: 2002 Aug |
Date Detail:
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Created Date: 2002-10-24 Completed Date: 2003-01-07 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9442138 Medline TA: J Card Fail Country: United States |
Other Details:
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Languages: eng Pagination: 225-31 Citation Subset: IM |
Affiliation:
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Department of Academic Cardiology, Castle Hill Hospital, Cottingham, Hull, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Airway Resistance / drug effects, physiology* Angiotensin-Converting Enzyme Inhibitors / therapeutic use Chronic Disease Exercise Test Female Forced Expiratory Volume / drug effects, physiology Heart Failure / drug therapy, physiopathology* Humans Male Middle Aged Oscillometry / methods* Predictive Value of Tests Pulmonary Gas Exchange / drug effects, physiology Receptors, Angiotensin / therapeutic use Smoking / adverse effects Statistics as Topic Vital Capacity / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Receptors, Angiotensin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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