| Airway remodeling: a potential therapeutic target in asthma. | |
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MedLine Citation:
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PMID: 21574028 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Apart from airway inflammation, airway remodeling is one of the main pathological features of asthma. However, it remains unclear when airway remodeling starts in children and whether it could be a potential therapeutic target in asthma. DATA SOURCES: We have reviewed the recent literature regarding structural changes after airway remodeling, the relationship between airway inflammation and airway remodeling, the relationship between childhood asthma and airway remodeling, and the role of long-term medication in asthma treatment for airway remodeling. RESULTS: The relationship between airway inflammation and airway remodeling is still controversial. A number of morphological and pathological studies have confirmed that airway remodeling occurs not only in adult asthma, but also in childhood asthma. It develops early in the disease process of asthma. At present, long-term medication in asthma treatment mainly focuses on anti-inflammation. However, there are no therapeutic interventions that revert airway remodeling once it is established. CONCLUSIONS: Airway remodeling may provide a possible new therapeutic target in the management of asthma. It is imperative to strengthen the research in developing new medications specifically for asthma airway remodeling. Prevention and treatment of airway remodeling become top priority in future asthma research. |
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Authors:
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Wei-Xi Zhang; Chang-Chong Li |
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Publication Detail:
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Type: Journal Article Date: 2011-05-15 |
Journal Detail:
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Title: World journal of pediatrics : WJP Volume: 7 ISSN: 1867-0687 ISO Abbreviation: World J Pediatr Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-05-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101278599 Medline TA: World J Pediatr Country: China |
Other Details:
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Languages: eng Pagination: 124-8 Citation Subset: IM |
Affiliation:
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Department of Respiratory Medicine, Yuying Children's Hospital, Wenzhou Medical College, Wenzhou, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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