| Airway reactivity in welders: a controlled prospective cohort study. | |
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MedLine Citation:
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PMID: 8978514 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a 3-year survey, respiratory symptoms, spirometry, and methacholine reactivity were measured annually in welders (n = 51) and non-welder controls subjects (n = 54) to determine whether welding-related symptoms are associated with accelerated decline in lung function or changes in airway reactivity. In the cross-workshift study, maximal midexpiratory flow rate declined reversibly during a welding day, whereas 1-second forced expiratory volume and forced-vital capacity were unchanged. In the longitudinal study, the welders had significantly more reversible work-related symptoms of cough, phlegm, wheeze, and chest tightness than the non-welder shipyard control subjects. In this group of actively working welders, across-workshift changes in midflow and reversible symptoms were related to the welding occupation, but evidence for chronic irreversible effects on spirometry or airway reactivity was not seen over the 3 years of observation. The short period of observation was not optimal for detecting a chronic effect on lung function. Work practices and engineering controls may be successfully preventing irreversible respiratory effects, but not mild reversible effects, in this group of welders. |
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Authors:
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W S Beckett; P E Pace; S J Sferlazza; G D Perlman; A H Chen; X P Xu |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine Volume: 38 ISSN: 1076-2752 ISO Abbreviation: J. Occup. Environ. Med. Publication Date: 1996 Dec |
Date Detail:
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Created Date: 1997-05-01 Completed Date: 1997-05-01 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9504688 Medline TA: J Occup Environ Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1229-38 Citation Subset: IM |
Affiliation:
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Occupational Medicine Program, Yale University School of Medicine, New Haven, Conn., USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Air Pollution / adverse effects* Analysis of Variance Bronchial Hyperreactivity / epidemiology* Case-Control Studies Cross-Over Studies Female Humans Linear Models Logistic Models Male Methacholine Chloride / adverse effects Multivariate Analysis Occupational Diseases / epidemiology* Ozone / analysis Prospective Studies Pulmonary Ventilation Respiration Disorders / epidemiology* Smoking / adverse effects Spirometry Time Factors United States / epidemiology Welding* |
| Grant Support | |
ID/Acronym/Agency:
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ES-00131/ES/NIEHS NIH HHS; HL02316/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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10028-15-6/Ozone; 62-51-1/Methacholine Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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