Document Detail


Airway reactivity in welders: a controlled prospective cohort study.
MedLine Citation:
PMID:  8978514     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In a 3-year survey, respiratory symptoms, spirometry, and methacholine reactivity were measured annually in welders (n = 51) and non-welder controls subjects (n = 54) to determine whether welding-related symptoms are associated with accelerated decline in lung function or changes in airway reactivity. In the cross-workshift study, maximal midexpiratory flow rate declined reversibly during a welding day, whereas 1-second forced expiratory volume and forced-vital capacity were unchanged. In the longitudinal study, the welders had significantly more reversible work-related symptoms of cough, phlegm, wheeze, and chest tightness than the non-welder shipyard control subjects. In this group of actively working welders, across-workshift changes in midflow and reversible symptoms were related to the welding occupation, but evidence for chronic irreversible effects on spirometry or airway reactivity was not seen over the 3 years of observation. The short period of observation was not optimal for detecting a chronic effect on lung function. Work practices and engineering controls may be successfully preventing irreversible respiratory effects, but not mild reversible effects, in this group of welders.
Authors:
W S Beckett; P E Pace; S J Sferlazza; G D Perlman; A H Chen; X P Xu
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine     Volume:  38     ISSN:  1076-2752     ISO Abbreviation:  J. Occup. Environ. Med.     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-05-01     Completed Date:  1997-05-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9504688     Medline TA:  J Occup Environ Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1229-38     Citation Subset:  IM    
Affiliation:
Occupational Medicine Program, Yale University School of Medicine, New Haven, Conn., USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Air Pollution / adverse effects*
Analysis of Variance
Bronchial Hyperreactivity / epidemiology*
Case-Control Studies
Cross-Over Studies
Female
Humans
Linear Models
Logistic Models
Male
Methacholine Chloride / adverse effects
Multivariate Analysis
Occupational Diseases / epidemiology*
Ozone / analysis
Prospective Studies
Pulmonary Ventilation
Respiration Disorders / epidemiology*
Smoking / adverse effects
Spirometry
Time Factors
United States / epidemiology
Welding*
Grant Support
ID/Acronym/Agency:
ES-00131/ES/NIEHS NIH HHS; HL02316/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
10028-15-6/Ozone; 62-51-1/Methacholine Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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