| Airway reactivity is a determinant of bronchodilator responsiveness after methacholine-induced bronchoconstriction. | |
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MedLine Citation:
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PMID: 15584317 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Airway hyperresponsiveness (AHR) is one of the characteristics of asthma and a risk factor for persistent airflow limitation. Poor response to bronchodilator may be a cause of persistent airflow limitation. Multiple factors may determine bronchodilator responsiveness, including airway reactivity to nonspecific bronchoconstrictive agents. If patients with AHR have poor bronchodilator responsiveness, then it could be a potential mechanism for asthma and persistent airflow limitation in these patients. The objective of this study is to assess the relationship between airway reactivity to methacholine and responsiveness to beta-agonist and beta-agonist/anticholinergic combination in a large subject population. A retrospective data analysis was undertaken of 764 consecutive subjects with > or = 20% reduction in forced expiratory volume during the first second of exhalation from total lung capacity (FEV1) after < or = 189 cumulative units of methacholine. The first 382 subjects received 3 inhalations of metaproterenol and the second 382 subjects received 3 inhalations of albuterol and ipratropium combination after > or = 20% reduction in FEV1. Bronchodilator responsiveness was measured as the percent increase in FEV1 after the treatment. Airway reactivity was assessed as the log10 of methacholine dose response slope. In a simple linear regression model, airway reactivity was significantly related to bronchodilator responsiveness. The coefficient of determination (r2) was 0.15 for the whole groups; 0.14 for metaproterenol group and 0.18 for albuterol/ipratropium combination group (all p<0.0001). The regression coefficient (beta) was 14.0 for the whole group; 14.8 and 13.2, respectively, for the two bronchodilator groups. Airway reactivity to methacholine is a determinant of airway responsiveness to both beta-agonist and beta-agonist/anticholinergic combination. Subjects with higher airway reactivity have higher bronchodilator responsiveness. |
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Authors:
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Annie Lin Parker |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The Journal of asthma : official journal of the Association for the Care of Asthma Volume: 41 ISSN: 0277-0903 ISO Abbreviation: J Asthma Publication Date: 2004 Sep |
Date Detail:
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Created Date: 2004-12-08 Completed Date: 2005-01-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8106454 Medline TA: J Asthma Country: United States |
Other Details:
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Languages: eng Pagination: 671-7 Citation Subset: IM |
Affiliation:
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Department of Pulmonary and Critical Care Medicine, Memorial Hospital of Rhode Island, Pawtucket, Rhode Island 02860, USA. Annie_Parker@brown.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Adolescent Adult Albuterol / administration & dosage Asthma / diagnosis, drug therapy*, physiopathology* Bronchial Hyperreactivity / diagnosis*, drug therapy* Bronchial Provocation Tests / methods Bronchodilator Agents / therapeutic use* Cohort Studies Dose-Response Relationship, Drug Drug Administration Schedule Drug Therapy, Combination Female Follow-Up Studies Humans Ipratropium / administration & dosage Linear Models Male Methacholine Chloride / diagnostic use Middle Aged Orciprenaline / administration & dosage Probability Respiratory Function Tests Retrospective Studies Sensitivity and Specificity Severity of Illness Index Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Bronchodilator Agents; 18559-94-9/Albuterol; 586-06-1/Orciprenaline; 60205-81-4/Ipratropium; 62-51-1/Methacholine Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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