Document Detail

Airway re-narrowing following deep inspiration in asthmatic and nonasthmatic subjects.
MedLine Citation:
PMID:  12882452     Owner:  NLM     Status:  MEDLINE    
After bronchoconstriction, deep inspiration (DI) causes dilatation followed by airway re-narrowing. Re-narrowing may be faster in asthmatic than nonasthmatic subjects. This study investigated the relationship between re-narrowing and the magnitude of both DI-induced dilatation and the volume-dependence of respiratory system resistance (Rrs) during tidal breathing. In 25 asthmatic and 18 nonasthmatic subjects the forced oscillation technique was used to measure Rrs at baseline and after methacholine challenge, during 1 min of tidal breathing, followed by DI to total lung capacity (TLC) and passive return to functional residual capacity (FRC). Dilatation was measured as the decrease in Rrs between end tidal inspiration and TLC, re-narrowing as Rrs at FRC immediately after DI, as per cent Rrs at end-tidal expiration, and volume dependent tidal fluctuation as the difference between mean Rrs at end-expiration and end-inspiration. Asthmatic subjects had greater re-narrowing, less dilatation, and greater tidal fluctuations both at baseline and after challenge. Re-narrowing correlated with baseline tidal fluctuation and inversely with dilatation. Both baseline tidal fluctuation and dilatation were significant independent predictors of re-narrowing. Following deep inspiration-induced dilatation, faster airway re-narrowing in asthmatic than nonasthmatic subjects is associated not only with reduced deep inspiration-induced dilatation but also with some property of the airways that is detectable prior to challenge as an increased volume dependence of resistance.
C M Salome; C W Thorpe; C Diba; N J Brown; N Berend; G G King
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The European respiratory journal     Volume:  22     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-07-28     Completed Date:  2003-12-15     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  62-8     Citation Subset:  IM    
Woolcock Institute of Medical Research and Cooperative Research Centre for Asthma, University of Sydney, Australia.
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MeSH Terms
Airway Resistance / drug effects,  physiology*
Asthma / physiopathology*
Bronchial Provocation Tests
Forced Expiratory Volume / drug effects
Inspiratory Capacity / drug effects
Linear Models
Methacholine Chloride / pharmacology
Middle Aged
Muscle, Smooth / drug effects,  physiopathology
Tidal Volume
Reg. No./Substance:
62-51-1/Methacholine Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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