Document Detail


Airway-parenchymal interdependence in the lung slice.
MedLine Citation:
PMID:  23128069     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The explanted lung slice has become a popular in vitro system for studying how airways contract. Because the forces of airway-parenchymal interdependence are such important modulators of airway narrowing, it is of significant interest to understand how the parenchyma around a constricting airway in a lung slice behaves. We have previously shown that the predictions of the 2-dimensional distortion field around a constricting airway are substantially different depending on whether the parenchyma is modeled as an elastic continuum versus a network of hexagonally arranged springs, which raises the question as to which model best explains the lung slice. We treated lung slices with methacholine and then followed the movement of a set of parenchymal landmarks around the airway as it narrowed. The resulting parenchymal displacement field was compared to the displacement fields predicted by the continuum and hexagonal spring network models. The predictions of the continuum model were much closer to the measured data than were those of the hexagonal spring network model, suggesting that the parenchyma in the lung slice behaves like an elastic continuum rather than a network of discrete springs. This may be because the alveoli of the lung slice are filled with agarose in order to provide structural stability, causing the parenchyma in the slice to act like a true mechanical continuum. How the air-filled parenchyma in the intact lung behave in vivo remains an open question.
Authors:
Baoshun Ma; Michael Sanderson; Jason H T Bates
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, N.I.H., Extramural     Date:  2012-11-02
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  185     ISSN:  1878-1519     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-25     Completed Date:  2013-06-07     Revised Date:  2014-01-23    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  211-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Airway Resistance / drug effects,  physiology*
Animals
Bronchi / anatomy & histology,  drug effects,  physiology,  ultrastructure
Bronchoconstrictor Agents / pharmacology
Elasticity
Lung / anatomy & histology,  drug effects,  physiology*,  ultrastructure
Methacholine Chloride / pharmacology
Models, Biological*
Muscle Contraction / drug effects,  physiology
Organ Culture Techniques
Stress, Mechanical*
Grant Support
ID/Acronym/Agency:
HL-103405/HL/NHLBI NIH HHS; R01 HL103405/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Bronchoconstrictor Agents; 0W5ETF9M2K/Methacholine Chloride
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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